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Descriptor English: Aprepitant
Descriptor Spanish: Aprepitant
Descriptor aprepitant
Entry term(s) (1-(3,5-bis(trifluorometil)fenil)etoxi)-3-(fluoro)fenil-4-(3-oxo-1,2,4-triazol-5-il)metilmorfolina
(2R)-(1R)-3,5-bis(trifluorometilfenil)etoxi)-(3S)-(4-fluoro)fenil-4-(3-(5-oxo-1H,4H-1,2,4-triazol)metil-morfolina
Emend
L 754,030
L 754030
L-754,030
L-754030
L754,030
L754030
MK 0517
MK 0869
MK 869
MK-0517
MK-0869
MK-869
MK0517
MK0869
MK869
Scope note: Antagonista morfolínico de los receptores de la neurocinina-1 (NK1) que se usa en el tratamiento de las náuseas y vómitos causados por la FARMACOTERAPIA y para la prevención de las NÁUSEAS Y VÓMITOS POSOPERATORIOS.
Descriptor Portuguese: Aprepitanto
Descriptor French: Aprépitant
Entry term(s): (1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
Emend
L 754,030
L 754030
L-754,030
L-754030
L754,030
L754030
MK 0517
MK 0869
MK 869
MK-0517
MK-0869
MK-869
MK0517
MK0869
MK869
Tree number(s): D03.383.533.640.125
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077608
Scope note: A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiemetics
Neurokinin-1 Receptor Antagonists
Registry Number: 1NF15YR6UY
CAS Type 1 Name: 3H-1,2,4-Triazol-3-one, 5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,4-dihydro-
Public MeSH Note: 2019; APREPITANT was indexed under MORPHOLINES 1998-2018
History Note: 2019 (1998)
DeCS ID: 57711
Unique ID: D000077608
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Aprepitant - Preferred
Concept UI M0447596
Scope note A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
Preferred term Aprepitant
MK 869 - Narrower
Concept UI M0295395
Preferred term MK 869
Entry term(s) MK 0869
MK-0869
MK-869
MK0869
MK869
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine - Related but not broader or narrower
Concept UI M000641045
Preferred term (2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
MK 0517 - Narrower
Concept UI M0529252
Preferred term MK 0517
Entry term(s) MK-0517
MK0517
(1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine - Narrower
Concept UI M0297559
Preferred term (1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
Emend - Narrower
Concept UI M0447597
Preferred term Emend
L 754030 - Narrower
Concept UI M0297563
Preferred term L 754030
Entry term(s) L 754,030
L-754,030
L-754030
L754,030
L754030



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