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Descriptor in English: Aprepitant
Descriptor in Spanish: Aprepitant
Descriptor in Portuguese: Aprepitanto
Descriptor in French: Aprépitant
Entry term(s): (1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
Emend
L 754,030
L 754030
L-754,030
L-754030
L754,030
L754030
MK 0517
MK 0869
MK 869
MK-0517
MK-0869
MK-869
MK0517
MK0869
MK869
Tree number(s): D03.383.533.640.125
Scope note: A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 2019 (1998)
DeCS UI: 57711
Descriptor UI: D000077608
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Aprepitant - Preferred
Concept UI M0447596
Scope note A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
Preferred term Aprepitant
MK 869 - Narrower
Concept UI M0295395
Preferred term MK 869
Entry term(s) MK 0869
MK-0869
MK-869
MK0869
MK869
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine - Related but not broader or narrower
Concept UI M000641045
Preferred term (2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
MK 0517 - Narrower
Concept UI M0529252
Preferred term MK 0517
Entry term(s) MK-0517
MK0517
(1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine - Narrower
Concept UI M0297559
Preferred term (1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
Emend - Narrower
Concept UI M0447597
Preferred term Emend
L 754030 - Narrower
Concept UI M0297563
Preferred term L 754030
Entry term(s) L 754,030
L-754,030
L-754030
L754,030
L754030



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