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Descriptor English: Amiloride
Descriptor Spanish: Amilorida
Descriptor amilorida
Entry term(s) amiloride
Scope note: Compueto de piracina que inhibe la reabsorción de SODIO a través de los CANALES DE SODIO en las CÉLULAS EPITELIALES renales. Dicha inhibición crea un potencial negativo en las membranas luminales de las células principales, localizadas en la porción distal del túbulo contorneado y el tubo colector. El potencial negativo reduce la secrecion de iones potasio e hidrógeno. La amilorida se utiliza asociada a DIURÉTICOS para evitar la pérdida de POTASIO. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Descriptor Portuguese: Amilorida
Descriptor French: Amiloride
Entry term(s): Amidal
Amiduret Trom
Amiloberag
Amiloride Hydrochloride
Amiloride Hydrochloride, Anhydrous
Anhydrous Amiloride Hydrochloride
Hydrochloride, Amiloride
Hydrochloride, Anhydrous Amiloride
Kaluril
Midamor
Midoride
Modamide
Trom, Amiduret
Tree number(s): D03.383.679.149
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000584
Scope note: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Diuretics
Acid Sensing Ion Channel Blockers
Epithelial Sodium Channel Blockers
Registry Number: 7DZO8EB0Z3
CAS Type 1 Name: Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-
Previous Indexing: Diuretics (1966-1971)
Pyrazines (1966-1971)
Public MeSH Note: 86; was see under PYRAZINES 1975-85
History Note: 86(72); was see under PYRAZINES 1975-85, was Prov 1972-74
DeCS ID: 588
Unique ID: D000584
NLM Classification: QV 160
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Amiloride - Preferred
Concept UI M0000906
Scope note A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Preferred term Amiloride
Amiduret Trom - Narrower
Concept UI M0432515
Preferred term Amiduret Trom
Entry term(s) Trom, Amiduret
Amiloberag - Narrower
Concept UI M0432516
Preferred term Amiloberag
Midoride - Narrower
Concept UI M0432518
Preferred term Midoride
Amiloride Hydrochloride, Anhydrous - Narrower
Concept UI M0330757
Preferred term Amiloride Hydrochloride, Anhydrous
Entry term(s) Anhydrous Amiloride Hydrochloride
Hydrochloride, Anhydrous Amiloride
Kaluril - Narrower
Concept UI M0432517
Preferred term Kaluril
Midamor - Narrower
Concept UI M0000907
Preferred term Midamor
Entry term(s) Modamide
Amidal - Narrower
Concept UI M0432514
Preferred term Amidal
Amiloride Hydrochloride - Narrower
Concept UI M0330756
Preferred term Amiloride Hydrochloride
Entry term(s) Hydrochloride, Amiloride



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