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Descriptor English: Mitochondrial Transmembrane Permeability-Driven Necrosis
Descriptor Spanish: Necrosis por Permeabilidad de la Transmembrana Mitocondrial
Descriptor necrosis por alteración de la permeabilidad de la membrana mitocondrial
Scope note: Forma de muerte celular regulada que se inicia por perturbaciones específicas del microambiente intracelular tales como ESTRÉS OXIDATIVO intenso y sobrecarga citosólica de CALCIO y que provoca la rotura osmótica de las MEMBRANAS MITOCONDRIALES.
Descriptor Portuguese: Necrose Dirigida por Permeabilidade Transmembrânica da Mitocôndria
Descriptor French: Nécrose induite par la perméabilité transmembranaire mitochondriale
Entry term(s): Mitochondrial Permeability Transition
Mitochondrial Transmembrane Permeability Driven Cell Death
Mitochondrial Transmembrane Permeability Driven Necrosis
Mitochondrial Transmembrane Permeability-Driven Cell Death
Tree number(s): G04.146.954.393
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000079530
Scope note: A form of regulated cell death that is initiated by specific perturbations of the intracellular microenvironment such as severe OXIDATIVE STRESS and cytosolic CALCIUM overload, which result in osmotic breakdown of the MITOCHONDRIAL MEMBRANES.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Cell Death (1993-2019)
Public MeSH Note: 2020
History Note: 2020
DeCS ID: 59157
Unique ID: D000079530
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/05/30
Mitochondrial Transmembrane Permeability-Driven Necrosis - Preferred
Concept UI M000644620
Scope note A form of regulated cell death that is initiated by specific perturbations of the intracellular microenvironment such as severe OXIDATIVE STRESS and cytosolic CALCIUM overload, which result in osmotic breakdown of the MITOCHONDRIAL MEMBRANES.
Preferred term Mitochondrial Transmembrane Permeability-Driven Necrosis
Entry term(s) Mitochondrial Transmembrane Permeability Driven Cell Death
Mitochondrial Transmembrane Permeability Driven Necrosis
Mitochondrial Transmembrane Permeability-Driven Cell Death
Mitochondrial Permeability Transition - Related but not broader or narrower
Concept UI M000644619
Preferred term Mitochondrial Permeability Transition



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