| Descriptor English: | Necroptosis | ||||
| Descriptor Spanish: |
Necroptosis
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| Descriptor Portuguese: | Necroptose | ||||
| Descriptor French: | Nécroptose | ||||
| Tree number(s): |
G04.146.954.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000079302 | ||||
| Scope note: | A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION. |
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| Annotation: | do not confuse with NECROSIS the pathological process |
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| Allowable Qualifiers: |
DE drug effects GE genetics IM immunology PH physiology RE radiation effects |
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| Previous Indexing: |
Necrosis (2005-2019) |
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| Public MeSH Note: | 2020 |
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| History Note: | 2020 |
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| DeCS ID: | 59170 | ||||
| Unique ID: | D000079302 | ||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||
| Date Established: | 2020/01/01 | ||||
| Date of Entry: | 2019/07/08 | ||||
| Revision Date: | 2019/05/30 |
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PHENOMENA AND PROCESSES
Cell Physiological Phenomena [G04]Cell Physiological Phenomena
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Necroptosis
- Preferred
| Concept UI |
M000644214 |
| Scope note | A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION. |
| Preferred term | Necroptosis |
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