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Descriptor English: Necroptosis
Descriptor Spanish: Necroptosis
Descriptor necroptosis
Scope note: Forma de muerte celular regulada que se inicia por perturbaciones de la homeostasis extracelular o intracelular que desencadenan una vía de muerte celular específica en la que interviene la activación de RIPK3 y MLKL (seudocinasa similar al dominio cinasa de linaje mixto). Los cambios morfológicos son, entre otros, tumefacción citoplasmática y organular, rotura de la MEMBRANA PLASMÁTICA y CONDENSACIÓN de la CROMATINA.
Descriptor Portuguese: Necroptose
Descriptor French: Nécroptose
Tree number(s): G04.146.954.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000079302
Scope note: A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION.
Annotation: do not confuse with NECROSIS the pathological process
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Necrosis (2005-2019)
Public MeSH Note: 2020
History Note: 2020
DeCS ID: 59170
Unique ID: D000079302
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/05/30
Necroptosis - Preferred
Concept UI M000644214
Scope note A form of regulated cell death initiated by perturbations of extracellular or intracellular homeostasis that trigger a specific cell death pathway involving the activation of RIPK3 and MLKL (mixed lineage kinase domain like pseudokinase). Morphological changes include cytoplasmic and organellar swelling, rupture of the PLASMA MEMBRANE, and CHROMATIN CONDENSATION.
Preferred term Necroptosis



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