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Descriptor English: Synucleinopathies
Descriptor Spanish: Sinucleinopatías
Descriptor sinucleinopatías
Entry term(s) alfa-sinucleinopatías
patología por alfa-sinucleína
sinucleinopatías alfa
Scope note: Trastornos neurodegenerativos en los que existe un depósito de ALFA-SINUCLEÍNA anormal en las neuronas dopaminérgicas y en las células gliales del encéfalo. Los agregados patológicos de la proteína alfa-sinucleína dan lugar a la formación de CUERPOS DE LEWY y de neuritas de Lewy, de gránulos de melanina en la SUSTANCIA NEGRA y en el LOCUS COERULEUS, y de inclusiones citoplasmáticas gliales. Las sinucleinopatías se asocian a una mutación en el gen de la ALFA-SINUCLEÍNA (SNCA) en el cromosoma 4. Algunos ejemplos destacados de sinucleinopatías son la ENFERMEDAD DE PARKINSON, la ENFERMEDAD CON CUERPOS DE LEWY con demencia y la ATROFIA DE MÚLTIPLES SISTEMAS.
Descriptor Portuguese: Sinucleinopatias
Descriptor French: Synucléinopathies
Entry term(s): Synucleinopathy
a-Synucleinopathies
a-Synucleinopathy
alpha Synuclein Pathologies
alpha Synuclein Pathology
alpha Synucleinopathies
alpha-Synucleinopathies
alpha-Synucleinopathy
Tree number(s): C10.574.928
C18.452.845.650
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000080874
Scope note: Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: Neurodegenerative Diseases (1998-2019)
alpha-Synuclein (1999-2019)
Public MeSH Note: 2020
History Note: 2020
Related: Lewy Bodies MeSH
alpha-Synuclein MeSH
DeCS ID: 59254
Unique ID: D000080874
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2020/01/01
Date of Entry: 2019/07/08
Revision Date: 2019/05/17
Synucleinopathies - Preferred
Concept UI M000648557
Scope note Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Preferred term Synucleinopathies
Entry term(s) Synucleinopathy
a-Synucleinopathies
a-Synucleinopathy
alpha Synuclein Pathologies
alpha Synuclein Pathology
alpha Synucleinopathies
alpha-Synucleinopathies
alpha-Synucleinopathy



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