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Descriptor English: Multiple System Atrophy
Descriptor Spanish: Atrofia de Múltiples Sistemas
Descriptor atrofia de múltiples sistemas
Scope note: Síndrome complejo compuesto por tres afecciones que representan las variantes clínicas del mismo proceso anatomopatológico: DEGENERACIÓN NIGROESTRIADA, SÍNDROME DE SHY-DRAGER y la forma esporádica de las ATROFIAS OLIVOPONTOCEREBELOSAS. Las características clínicas incluyen disfunción de los ganglios autonómicos, cerebelosos y basales. El examen anatomopatológico revela atrofia de los ganglios basales, cerebelo, protuberancia, y médula, con pérdida prominente de neuronas autonómicas en el tronco cerebral y en la médula espinal. (Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Descriptor Portuguese: Atrofia de Múltiplos Sistemas
Descriptor French: Atrophie multisystématisée
Entry term(s): Atrophies, Multisystem
Atrophies, Multisystemic
Atrophy, Multiple System
Atrophy, Multisystem
Atrophy, Multisystemic
Multiple System Atrophies
Multiple System Atrophy Syndrome
Multisystem Atrophies
Multisystem Atrophy
Multisystemic Atrophies
Multisystemic Atrophy
Tree number(s): C10.177.575.550
C10.228.140.079.612
C10.228.662.550
C10.574.928.625
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D019578
Scope note: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Annotation: a specific neurodegenerative syndrome complex; not for atrophy in other systems
Allowable Qualifiers: BL blood
CF cerebrospinal fluid
CI chemically induced
CL classification
CN congenital
CO complications
DG diagnostic imaging
DH diet therapy
DI diagnosis
DT drug therapy
EC economics
EH ethnology
EM embryology
EN enzymology
EP epidemiology
ET etiology
GE genetics
HI history
IM immunology
ME metabolism
MI microbiology
MO mortality
NU nursing
PA pathology
PC prevention & control
PP physiopathology
PS parasitology
PX psychology
RH rehabilitation
RT radiotherapy
SU surgery
TH therapy
UR urine
VE veterinary
VI virology
Previous Indexing: Autonomic Nervous System Diseases (1981-1997)
Brain Diseases (1981-1993)
Nervous System Diseases (1969-1997)
Shy-Drager Syndrome (1981-1997)
Public MeSH Note: 1998
History Note: 1998
Related: Olivopontocerebellar Atrophies MeSH
Shy-Drager Syndrome MeSH
DeCS ID: 33352
Unique ID: D019578
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2013/07/08
Multiple System Atrophy - Preferred
Concept UI M0029076
Scope note A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)
Preferred term Multiple System Atrophy
Entry term(s) Atrophies, Multisystem
Atrophies, Multisystemic
Atrophy, Multiple System
Atrophy, Multisystem
Atrophy, Multisystemic
Multiple System Atrophies
Multiple System Atrophy Syndrome
Multisystem Atrophies
Multisystem Atrophy
Multisystemic Atrophies
Multisystemic Atrophy



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