| Descriptor English: | Immune Checkpoint Inhibitors | ||||||
| Descriptor Spanish: |
Inhibidores de Puntos de Control Inmunológico
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| Descriptor Portuguese: | Inibidores de Checkpoint Imunológico | ||||||
| Descriptor French: | Inhibiteurs de points de contrôle immunitaires | ||||||
| Entry term(s): |
Blockade, PD-1-PD-L1 CTLA 4 Inhibitor CTLA 4 Inhibitors CTLA-4 Inhibitor CTLA-4 Inhibitors Checkpoint Blockade, Immune Checkpoint Blockers, Immune Checkpoint Inhibition, Immune Checkpoint Inhibitor, Immune Checkpoint Inhibitors, Immune Cytotoxic T Lymphocyte Associated Protein 4 Inhibitor Cytotoxic T Lymphocyte Associated Protein 4 Inhibitors Cytotoxic T-Lymphocyte-Associated Protein 4 Inhibitor Cytotoxic T-Lymphocyte-Associated Protein 4 Inhibitors Immune Checkpoint Blockade Immune Checkpoint Blockers Immune Checkpoint Inhibition Immune Checkpoint Inhibitor Inhibitor, PD-1 PD 1 Inhibitor PD 1 Inhibitors PD 1 PD L1 Blockade PD L1 Inhibitor PD L1 Inhibitors PD-1 Inhibitor PD-1 Inhibitors PD-1-PD-L1 Blockade PD-L1 Inhibitor PD-L1 Inhibitors Programmed Cell Death Protein 1 Inhibitor Programmed Cell Death Protein 1 Inhibitors Programmed Death Ligand 1 Inhibitors Programmed Death-Ligand 1 Inhibitors |
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| Tree number(s): |
D27.505.519.507 D27.505.954.248.384.500 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000082082 | ||||||
| Scope note: | Drugs that block negative regulator IMMUNE CHECKPOINT proteins (e.g., PD-1 RECEPTOR and CTLA-4 ANTIGEN) thereby increasing suppressed immune activation in immunotherapies. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Previous Indexing: |
Antineoplastic Agents (2017-2020) |
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| Public MeSH Note: | 2021 |
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| History Note: | 2021 |
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| DeCS ID: | 59322 | ||||||
| Unique ID: | D000082082 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2021/01/01 | ||||||
| Date of Entry: | 2020/07/07 | ||||||
| Revision Date: | 2020/05/27 |
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CHEMICALS AND DRUGS
Chemical Actions and Uses [D27]Chemical Actions and Uses -
CHEMICALS AND DRUGS
Chemical Actions and Uses [D27]Chemical Actions and Uses
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Immune Checkpoint Inhibitors
- Preferred
Immune Checkpoint Blockade
- Broader
PD-L1 Inhibitors
- Narrower
CTLA-4 Inhibitors
- Narrower
PD-1 Inhibitors
- Narrower
PD-1-PD-L1 Blockade
- Narrower
| Concept UI |
M000675754 |
| Scope note | Drugs that block negative regulator IMMUNE CHECKPOINT proteins (e.g., PD-1 RECEPTOR and CTLA-4 ANTIGEN) thereby increasing suppressed immune activation in immunotherapies. |
| Preferred term | Immune Checkpoint Inhibitors |
| Entry term(s) |
Checkpoint Blockers, Immune Checkpoint Inhibitor, Immune Checkpoint Inhibitors, Immune Immune Checkpoint Blockers Immune Checkpoint Inhibitor |
| Concept UI |
M000677227 |
| Preferred term | Immune Checkpoint Blockade |
| Entry term(s) |
Checkpoint Blockade, Immune Checkpoint Inhibition, Immune Immune Checkpoint Inhibition |
| Concept UI |
M000678017 |
| Preferred term | PD-L1 Inhibitors |
| Entry term(s) |
PD L1 Inhibitor PD L1 Inhibitors PD-L1 Inhibitor Programmed Death Ligand 1 Inhibitors Programmed Death-Ligand 1 Inhibitors |
| Concept UI |
M000675755 |
| Preferred term | CTLA-4 Inhibitors |
| Entry term(s) |
CTLA 4 Inhibitor CTLA 4 Inhibitors CTLA-4 Inhibitor Cytotoxic T Lymphocyte Associated Protein 4 Inhibitor Cytotoxic T Lymphocyte Associated Protein 4 Inhibitors Cytotoxic T-Lymphocyte-Associated Protein 4 Inhibitor Cytotoxic T-Lymphocyte-Associated Protein 4 Inhibitors |
| Concept UI |
M000675756 |
| Preferred term | PD-1 Inhibitors |
| Entry term(s) |
Inhibitor, PD-1 PD 1 Inhibitor PD 1 Inhibitors PD-1 Inhibitor Programmed Cell Death Protein 1 Inhibitor Programmed Cell Death Protein 1 Inhibitors |
| Concept UI |
M000678018 |
| Preferred term | PD-1-PD-L1 Blockade |
| Entry term(s) |
Blockade, PD-1-PD-L1 PD 1 PD L1 Blockade |
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