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Descriptor English: Antigenic Drift and Shift
Descriptor Spanish: Deriva y Cambio Antigénico
Descriptor variaciones antigénicas menores y mayores
Entry term(s) deriva antigénica
escape antigénico
variaciones antigénicas mayores y menores
variación antigénica mayor
variación antigénica mayor y menor
variación antigénica menor
variación antigénica menor y mayor
Scope note: Cambios en la población de ANTÍGENOS por mutaciones lentas y menores (variaciones antigénicas menores o deriva antigénica) o mutaciones súbitas y mayores (variaciones antigénicas mayores o cambio antigénico). La acumulación de mutaciones menores en las variaciones antigénicas menores a lo largo del tiempo puede requerir el desarrollo de una nueva vacuna (por ejemplo, VACUNAS DE LA GRIPE estacionales). Por otro lado, las variaciones antigénicas mayores son menos frecuentes, pero pueden provocar la aparición de un nuevo subtipo o especie y, a veces, pandemias (por ejemplo, pandemia del H1N1 en 2009 y 2018 y la pandemia de COVID-19) debido a la falta de INMUNIDAD DE GRUPO al nuevo patógeno recién surgido.
Descriptor Portuguese: Deriva e Deslocamento Antigênicos
Descriptor French: Dérive et cassure antigéniques
Entry term(s): Antigen Drift
Antigen Drift and Shift
Antigen Escape
Antigen Shift
Antigen Shift and Drift
Antigenic Drift
Antigenic Escape
Antigenic Shift
Antigenic Shift and Drift
Drift, Antigen
Drift, Antigenic
Escape, Antigen
Escape, Antigenic
Shift, Antigen
Shift, Antigenic
Tree number(s): G05.045.300.500
G05.330.320.500
G05.365.073.500
G12.500.249.500
G16.075.300.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000088603
Scope note: Changes in the ANTIGEN population by slow and minor (antigenic drift) or sudden and major mutations (antigenic shift). Accumulation of minor mutations in antigenic drift over time may require development of new vaccine (e.g., seasonal FLU VACCINES). Antigenic shift on the other hand is less common but may result in emergence of a new subtype or species and sometimes pandemics (e.g., H1N1 pandemics in 2009 and 2018 and COVID-19) due to lack of HERD IMMUNITY to the newly emerged novel pathogen.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Antigenic Variation (1990-2021)
Public MeSH Note: 2022
History Note: 2022
DeCS ID: 59690
Unique ID: D000088603
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/06/30
Antigenic Drift and Shift - Preferred
Concept UI M000742027
Scope note Changes in the ANTIGEN population by slow and minor (antigenic drift) or sudden and major mutations (antigenic shift). Accumulation of minor mutations in antigenic drift over time may require development of new vaccine (e.g., seasonal FLU VACCINES). Antigenic shift on the other hand is less common but may result in emergence of a new subtype or species and sometimes pandemics (e.g., H1N1 pandemics in 2009 and 2018 and COVID-19) due to lack of HERD IMMUNITY to the newly emerged novel pathogen.
Preferred term Antigenic Drift and Shift
Entry term(s) Antigen Drift and Shift
Antigen Shift and Drift
Antigenic Shift and Drift
Antigenic Shift - Narrower
Concept UI M000742029
Preferred term Antigenic Shift
Entry term(s) Antigen Shift
Shift, Antigen
Shift, Antigenic
Antigenic Escape - Narrower
Concept UI M000742030
Preferred term Antigenic Escape
Entry term(s) Antigen Escape
Escape, Antigen
Escape, Antigenic
Antigenic Drift - Narrower
Concept UI M000742028
Preferred term Antigenic Drift
Entry term(s) Antigen Drift
Drift, Antigen
Drift, Antigenic



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