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Descriptor English: Phase Variation
Descriptor Spanish: Variación de la Fase
Descriptor variación de fase
Entry term(s) fasevariones
regulones de fase variable
Scope note: Mecanismo adaptativo utilizado por los microorganismos para evitar la detección por parte del huésped o para adaptarse a los cambios del entorno mediante la activación y desactivación aleatorias y rápidas de un gen por medio de diversos mecanismos entre las fases de activación y desactivación. Por ejemplo, MYCOBACTERIUM TUBERCULOSIS tolerante a los fármacos surge mediante mutaciones reversibles rápidas en el gen glpK mediante variación de fase.
Descriptor Portuguese: Variação de Fase
Descriptor French: Variation de phase
Entry term(s): Phase Variable Regulons
Phase Variations
Phase-Variable Regulon
Phase-Variable Regulons
Phasevarion
Phasevarions
Regulon, Phase-Variable
Variation, Phase
Tree number(s): G05.365.693
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000090502
Scope note: An adaptive mechanism used by microbes to avoid detection by the host or adapt to changes in environment by randomly and rapidly switch on and off of a gene by various mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS arises through rapid reversible mutations in the glpK gene through phase variation.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Public MeSH Note: 2022
History Note: 2022
DeCS ID: 59804
Unique ID: D000090502
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/05/10
Phase Variation - Preferred
Concept UI M000746585
Scope note An adaptive mechanism used by microbes to avoid detection by the host or adapt to changes in environment by randomly and rapidly switch on and off of a gene by various mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS arises through rapid reversible mutations in the glpK gene through phase variation.
Preferred term Phase Variation
Entry term(s) Phase Variations
Variation, Phase
Phasevarions - Related but not broader or narrower
Concept UI M000746586
Preferred term Phasevarions
Entry term(s) Phase Variable Regulons
Phase-Variable Regulon
Phase-Variable Regulons
Phasevarion
Regulon, Phase-Variable



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