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Descriptor English: Antibody Diversity
Descriptor Spanish: Diversidad de Anticuerpos
Descriptor diversidad de anticuerpos
Entry term(s) teoría de la línea germinal
Scope note: El fenómeno de la inmensa variabilidad característica de los ANTICUERPOS. Esto posibilita que el SISTEMA INMUNOLÓGICO reaccione específicamente frente a tipos esencialmente ilimitados de ANTÍGENOS. La diversidad de los anticuerpos se explica por tres teorías principales: (1) la Teoría de la línea germinal, que sostiene que cada célula productora de anticuerpo posee genes que codifican todos los posibles anticuerpos pero expresan solo el estimulado por el antígeno, (2) la Teoría de la mutación somática según la cual las células productoras de anticuerpos contienen solo unos pocos genes que producen diversidad de anticuerpos mediante mutación, y la (3) Teoría del reordenamiento génico, según la cual la diversidad de los anticuerpos se genera mediante el reordenamiento de segmentos del gen de la REGIÓN VARIABLE DE INMUNOGLOBULINAS durante la diferenciación de las CÉLULAS PRODUCTORAS DE ANTICUERPOS.
Descriptor Portuguese: Diversidade de Anticorpos
Descriptor French: Diversité des anticorps
Entry term(s): Antibody Diversities
Diversities, Antibody
Diversity, Antibody
Germ Line Theories
Germ Line Theory
Theories, Germ Line
Theory, Germ Line
Tree number(s): G05.365.036
G12.500.199
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000916
Scope note: The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Antibodies (1966-1969)
Antibody Specificity (1970-1979)
Public MeSH Note: 80
History Note: 80
DeCS ID: 926
Unique ID: D000916
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1980/01/01
Date of Entry: 1979/02/23
Revision Date: 2015/06/22
Antibody Diversity - Preferred
Concept UI M0001364
Scope note The phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS.
Preferred term Antibody Diversity
Entry term(s) Antibody Diversities
Diversities, Antibody
Diversity, Antibody
Germ Line Theory - Narrower
Concept UI M0001365
Preferred term Germ Line Theory
Entry term(s) Germ Line Theories
Theories, Germ Line
Theory, Germ Line



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