| Descriptor English: | RNA, Guide, CRISPR-Cas Systems | ||||||
| Descriptor Spanish: |
ARN Guía de Sistemas CRISPR-Cas
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| Descriptor Portuguese: | RNA Guia de Sistemas CRISPR-Cas | ||||||
| Descriptor French: | Without translation | ||||||
| Entry term(s): |
CRISPR Guide RNA CRISPR-Cas Systems sgRNA (Single Guide RNA) Guide RNA (CRISPR-Cas Systems) Guide RNA, CRISPR Guide RNA, CRISPR Cas Systems Guide RNA, CRISPR-Cas Systems Guide RNA, Single RNA, CRISPR Guide RNA, Guide (CRISPR-Cas Systems) RNA, Single Guide RNA, Single-Guide Single Guide RNA Single-Guide RNA Transactivating crRNA crRNA crRNA, Transactivating sgRNA (CRISPR-Cas Systems) sgRNA (Single-Guide RNA) tracrRNA |
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| Tree number(s): |
D13.444.735.790.552.563 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000094704 | ||||||
| Scope note: | A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING. |
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| Annotation: | do not confuse with RNA, GUIDE, KINETOPLASTIDA; do not confuse sgRNA (SINGLE-GUIDE RNA) with sgRNA (SUBGENOMIC RNA) |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
CRISPR-Cas Systems (2014-2022) RNA, Guide, CRISPR-Cas Systems (2008-2022) |
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| Public MeSH Note: | 2023 |
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| History Note: | 2023 |
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| Related: |
CRISPR-Cas Systems
MeSH | ||||||
| DeCS ID: | 60283 | ||||||
| Unique ID: | D000094704 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2023/01/01 | ||||||
| Date of Entry: | 2022/07/11 | ||||||
| Revision Date: | 2022/07/11 |
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|
RNA, Guide, CRISPR-Cas Systems
- Preferred
RNA, CRISPR Guide
- Narrower
RNA, Single Guide
- Narrower
crRNA, Transactivating
- Narrower
| Concept UI |
M000756254 |
| Scope note | A component of CRISPR-Cas SYSTEMS. Cas endodeoxyribonucleases assemble with a guide RNA complex, a hybrid of CRISPR RNA (crRNA) and transactivating crRNA (tracrRNA) molecules, to form an active complex that cleaves DNA. crRNA and tracrRNA can be synthetically fused into a single RNA molecule, namely single guide RNA. Synthetic sgRNA is used with CRISPR-Cas SYSTEMS for targeted GENE EDITING. |
| Preferred term | RNA, Guide, CRISPR-Cas Systems |
| Entry term(s) |
Guide RNA (CRISPR-Cas Systems) Guide RNA, CRISPR Cas Systems Guide RNA, CRISPR-Cas Systems RNA, Guide (CRISPR-Cas Systems) |
| Concept UI |
M000756255 |
| Preferred term | RNA, CRISPR Guide |
| Entry term(s) |
CRISPR Guide RNA Guide RNA, CRISPR crRNA |
| Concept UI |
M000756256 |
| Preferred term | RNA, Single Guide |
| Entry term(s) |
CRISPR-Cas Systems sgRNA (Single Guide RNA) Guide RNA, Single RNA, Single-Guide Single Guide RNA Single-Guide RNA sgRNA (CRISPR-Cas Systems) sgRNA (Single-Guide RNA) |
| Concept UI |
M000756258 |
| Preferred term | crRNA, Transactivating |
| Entry term(s) |
Transactivating crRNA tracrRNA |
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