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Descriptor English: MicroRNAs
Descriptor Spanish: MicroARNs
Descriptor microARN
Entry term(s) ARN temporal pequeño
miRNA
miRNAs
micro ARN
micro ARNs
micro RNA
micro RNAs
microARNs
microRNA
microRNA primario
microRNAs
pri-miRNA
stRNA
Scope note: ARN bicatenarios pequeños, no codificadores de proteínas, con una longitud de 21-25 nucleótidos, que son formados a partir de transcritos génicos de microARN monocatenarios por la misma RIBONUCLEASA III, Dicer, que produce ARN INTERFERENTES PEQUEÑOS. Pasan a formar parte del COMPLEJO DEL SILENCIAMIENTO INDUCIDO POR EL ARN y reprimen la traducción (TRADUCCIÓN GENÉTICA) de determinados ARN mediante la unión a la región 3'UTR homóloga como apareamiento imperfecto. Los ARN temporales pequeños (stRNA), let-7 y lin-4, de C. elegans, son los 2 primeros miRNA descubiertos y pertenecen a la clase de miRNA implicados en la cronología del desarrollo.
Descriptor Portuguese: MicroRNAs
Descriptor French: microARN
Entry term(s): Micro RNA
MicroRNA
MicroRNA, Primary
Primary MicroRNA
Primary miRNA
RNA, Micro
RNA, Small Temporal
Small Temporal RNA
Temporal RNA, Small
miRNA
miRNA, Primary
miRNAs
pre miRNA
pre-miRNA
pri miRNA
pri-miRNA
stRNA
Tree number(s): D13.150.650.319
D13.444.735.150.319
D13.444.735.790.552.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D035683
Scope note: Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: RNA, Antisense (2001-2002)
RNA, Untranslated (2001-2002)
Public MeSH Note: 2003; MICRORNAS was indexed under RNA, UNTRANSLATED and RNA, ANTISENSE 2001-2002
History Note: 2003; use MICRORNAS (NM) 2001-2002
Related: RNA, Small Interfering MeSH
DeCS ID: 37535
Unique ID: D035683
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2013/07/09
MicroRNAs - Preferred
Concept UI M0407989
Scope note Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Preferred term MicroRNAs
Entry term(s) Micro RNA
MicroRNA
RNA, Micro
miRNA
miRNAs
Primary MicroRNA - Narrower
Concept UI M0507098
Scope note The RNA transcript of the miRNA genes prior to processing to pre-miRNA.
Preferred term Primary MicroRNA
Entry term(s) MicroRNA, Primary
Primary miRNA
miRNA, Primary
pri miRNA
pri-miRNA
RNA, Small Temporal - Narrower
Concept UI M0408369
Scope note A class of microRNAs that regulate developmental timing.
Preferred term RNA, Small Temporal
Entry term(s) Small Temporal RNA
Temporal RNA, Small
stRNA
pre-miRNA - Narrower
Concept UI M0507502
Scope note Precursors to miRNA generated from pri-miRNA. They are exported from the nucleus where they are further processed by Dicer RNase to generate mature miRNA.
Preferred term pre-miRNA
Entry term(s) pre miRNA



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