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Descriptor English: Glutamate-Ammonia Ligase
Descriptor Spanish: Glutamato-Amoníaco Ligasa
Descriptor glutamato-amoníaco ligasa
Entry term(s) glutamina sintetasa
Scope note: Enzima que cataliza la conversión del ATP, L-glutamato y NH3 a ADP, ortofosfato y L-glutamina. Actúa también más lentamente sobre el 4-metileno-L-glutamato. (Enzyme Nomenclature, 1992) EC 6.3.1.2.
Descriptor Portuguese: Glutamato-Amônia Ligase
Descriptor French: Glutamate-ammonia ligase
Entry term(s): Glutamate Ammonia Ligase
Glutamate Ammonia Ligase (ADP)
Glutamine Synthetase
Ligase, Glutamate-Ammonia
Synthetase, Glutamine
Tree number(s): D08.811.464.259.200.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005974
Scope note: An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 6.3.1.2
CAS Type 1 Name: L-Glutamate:ammonia ligase (ADP-forming)
Previous Indexing: Ligases (1966-1971)
Public MeSH Note: 95; was GLUTAMINE SYNTHETASE 1972-94
Online Note: use GLUTAMATE-AMMONIA LIGASE to search GLUTAMINE SYNTHETASE 1972-94
History Note: 95; was GLUTAMINE SYNTHETASE 1972-94
DeCS ID: 6118
Unique ID: D005974
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09
Glutamate-Ammonia Ligase - Preferred
Concept UI M0009384
Scope note An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
Preferred term Glutamate-Ammonia Ligase
Entry term(s) Glutamate Ammonia Ligase
Glutamate Ammonia Ligase (ADP)
Glutamine Synthetase
Ligase, Glutamate-Ammonia
Synthetase, Glutamine



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