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Descriptor English: GTP Cyclohydrolase
Descriptor Spanish: GTP Ciclohidrolasa
Descriptor GTP ciclohidrolasa
Entry term(s) GTP 8-formilhidrolasa
GTP dihidrolasa
enzima de abertura del anillo GTP
Scope note: (GTP ciclohidrolasa I) o GTP 7,8-8,9-dihidrolasa (formadora de pirofosfato) (GTP ciclohidrolasa II). Grupo enzimático que hidroliza el anillo imidazólico del GTP, liberando el carbono 8 como formiato. Dos enlaces C-N son hidrolizados y se isomeriza la unidad de pentosa. Este es el primer paso en la síntesis de ácido fólico a partir de GTP. EC 3.5.4.16 (GTP ciclohidrolasa I) y EC 3.5.4.25 (GTP ciclohidrolasa II).
Descriptor Portuguese: GTP Cicloidrolase
Descriptor French: GTP cyclohydrolase I
Entry term(s): 7,8 Dihydroneopterintriphosphate Synthetase
7,8-Dihydroneopterintriphosphate Synthetase
8-Formylhydrolase, GTP
Cyclohydrolase I, GTP
Cyclohydrolase II, GTP
Cyclohydrolase, GTP
Dihydrolase, GTP
GTP 8 Formylhydrolase
GTP 8-Formylhydrolase
GTP Cyclohydrolase I
GTP Cyclohydrolase II
GTP Dihydrolase
GTP Ring Opening Enzyme
GTP Ring-Opening Enzyme
Ring-Opening Enzyme, GTP
Synthetase, 7,8-Dihydroneopterintriphosphate
Tree number(s): D08.811.277.151.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006136
Scope note: (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.5.4.16
CAS Type 1 Name: GTP 7,8-8,9-dihydrolase
Previous Indexing: Aminohydrolases (1974)
Guanosine Triphosphate (1974)
Public MeSH Note: 91; was see under AMINOHYDROLASES 1975-90
History Note: 91(75); was see under AMINOHYDROLASES 1975-90
DeCS ID: 6285
Unique ID: D006136
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2003/07/09
GTP Cyclohydrolase - Preferred
Concept UI M0009663
Scope note (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).
Preferred term GTP Cyclohydrolase
Entry term(s) 7,8 Dihydroneopterintriphosphate Synthetase
7,8-Dihydroneopterintriphosphate Synthetase
8-Formylhydrolase, GTP
Cyclohydrolase, GTP
Dihydrolase, GTP
GTP 8 Formylhydrolase
GTP 8-Formylhydrolase
GTP Dihydrolase
GTP Ring Opening Enzyme
GTP Ring-Opening Enzyme
Ring-Opening Enzyme, GTP
Synthetase, 7,8-Dihydroneopterintriphosphate
GTP Cyclohydrolase II - Narrower
Concept UI M0009665
Preferred term GTP Cyclohydrolase II
Entry term(s) Cyclohydrolase II, GTP
GTP Cyclohydrolase I - Narrower
Concept UI M0009664
Preferred term GTP Cyclohydrolase I
Entry term(s) Cyclohydrolase I, GTP



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