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Descriptor English: Guanylyl Imidodiphosphate
Descriptor Spanish: Guanilil Imidodifosfato
Descriptor guanilil imidodifosfato
Entry term(s) GMP-PNP
Scope note: Análogo no-hidrolizable del GTP, en el que el átomo de oxígeno que une los fosfatos beta y gamma es reemplazado por un átomo de nitrógeno. Se une fuertemente a la proteína G en presencia de Mg2+. El nucleótido es un inhibidor potente de la ADENILATO CICLASA.
Descriptor Portuguese: Guanilil Imidodifosfato
Descriptor French: Guanylyl imidodiphosphate
Entry term(s): GMP-P(NH)P
GMP-PNP
Gpp(NH)p
Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
Guanyl 5' Imidodiphosphate
Guanyl-5'-Imidodiphosphate
Imidodiphosphate, Guanylyl
P(NH)PPG
Tree number(s): D03.633.100.759.646.454.504.400
D13.695.667.454.504.400
D13.695.827.426.504.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006165
Scope note: A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 34273-04-6
CAS Type 1 Name: 5'-Guanylic acid, monoanhydride with imidodiphosphoric acid
Previous Indexing: Guanine Nucleotides (1966-1977)
Guanosine Triphosphate (1972-1977)
Public MeSH Note: 91; was see under GUANOSINE TRIPHOSPHATE 1978-90
History Note: 91(78); was see under GUANOSINE TRIPHOSPHATE 1978-90
Entry Version: GPPNHP
DeCS ID: 6315
Unique ID: D006165
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/04/22
Revision Date: 2016/05/31
Guanylyl Imidodiphosphate - Preferred
Concept UI M0009703
Scope note A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of ADENYLYL CYCLASES.
Preferred term Guanylyl Imidodiphosphate
Entry term(s) GMP-P(NH)P
GMP-PNP
Gpp(NH)p
Guanosine 5'-(Beta,Gamma-Imido)Triphosphate
Guanyl 5' Imidodiphosphate
Guanyl-5'-Imidodiphosphate
Imidodiphosphate, Guanylyl
P(NH)PPG



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