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Descriptor English: Meglutol
Descriptor Spanish: Meglutol
Descriptor meglutol
Entry term(s) ácido 3-hidroxi-3-metilglutárico
Scope note: Antilipémico que disminuye las concentraciones de colesterol, triglicéridos, betalipoproteínas séricas y fosfolípidos. Actúa interfiriendo en los pasos enzimáticos de la conversión de acetato a hidroximetilglutaril coenzima A así como inhibiendo la actividad de las HIDROXIMETILGLUTARIL COA REDUCTASAS que es la enzima limitante de la velocidad en la biosíntesis del colesterol.
Descriptor Portuguese: Meglutol
Descriptor French: Méglutol
Entry term(s): 3 Hydroxy 3 methylglutaric Acid
3 Hydroxy 3 methylpentanedioic Acid
3-Hydroxy-3-methylglutaric Acid
3-Hydroxy-3-methylpentanedioic Acid
Acid, 3-Hydroxy-3-methylglutaric
Acid, 3-Hydroxy-3-methylpentanedioic
beta Hydroxy beta Methylglutarate
beta-Hydroxy-beta-Methylglutarate
Tree number(s): D02.241.081.337.351.550
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015093
Scope note: An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anticholesteremic Agents
Hypolipidemic Agents
Enzyme Inhibitors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number: CLA99KCD53
CAS Type 1 Name: Pentanedioic acid, 3-hydroxy-3-methyl-
Previous Indexing: Anticholesteremic Agents (1966-1979)
Antilipemic Agents (1966-1972)
Glutarates (1966-1979)
Hydroxy Acids (1975-1979)
Public MeSH Note: 96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
History Note: 96; was 3-HYDROXY-3-METHYLGLUTARIC ACID 1980-95 (see under GLUTARATES 1980-90)
DeCS ID: 7073
Unique ID: D015093
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1979/05/23
Revision Date: 2013/07/08
Meglutol - Preferred
Concept UI M0023214
Scope note An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.
Preferred term Meglutol
Entry term(s) 3 Hydroxy 3 methylglutaric Acid
3 Hydroxy 3 methylpentanedioic Acid
3-Hydroxy-3-methylglutaric Acid
3-Hydroxy-3-methylpentanedioic Acid
Acid, 3-Hydroxy-3-methylglutaric
Acid, 3-Hydroxy-3-methylpentanedioic
beta Hydroxy beta Methylglutarate
beta-Hydroxy-beta-Methylglutarate



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