| Descriptor English: | Hypoxanthine Phosphoribosyltransferase | ||||||
| Descriptor Spanish: |
Hipoxantina Fosforribosiltransferasa
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| Descriptor Portuguese: | Hipoxantina Fosforribosiltransferase | ||||||
| Descriptor French: | Hypoxanthine phosphoribosyltransferase | ||||||
| Entry term(s): |
Guanine Phosphoribosyltransferase HGPRT HPRT HPRTase Hypoxanthine Guanine Phosphoribosyltransferase Hypoxanthine-Guanine Phosphoribosyltransferase IMP Pyrophosphorylase Phosphoribosyltransferase, Guanine Phosphoribosyltransferase, Hypoxanthine Phosphoribosyltransferase, Hypoxanthine-Guanine Pyrophosphorylase, IMP |
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| Tree number(s): |
D08.811.913.400.725.450 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D007041 | ||||||
| Scope note: | An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8. |
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| Annotation: | /defic: consider also LESCH-NYHAN SYNDROME or GOUT; DF: note short X ref |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.4.2.8 | ||||||
| CAS Type 1 Name: | IMP:pyrophosphate phospho-D-ribosyltransferase | ||||||
| Previous Indexing: |
Pentosephosphates (1972-1974) Pentosyltransferases (1972-1974) |
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| Public MeSH Note: | 75; GUANINE PHOSPHORIBOSYLTRANSFERASE was indexed under PENTOSYLTRANSFERASES 1978-91 |
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| Online Note: | use HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE (NM) to search GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1980-91 |
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| History Note: | 75; GUANINE PHOSPHORIBOSYLTRANSFERASE was GUANINE PHOSPHORIBOSYLTRANSFERASE (NM) 1978-91 |
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| Related: |
Gout
MeSH Lesch-Nyhan Syndrome MeSH | ||||||
| DeCS ID: | 7221 | ||||||
| Unique ID: | D007041 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1975/09/01 | ||||||
| Date of Entry: | 1974/11/11 | ||||||
| Revision Date: | 2017/07/13 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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Hypoxanthine Phosphoribosyltransferase
- Preferred
| Concept UI |
M0010952 |
| Scope note | An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8. |
| Preferred term | Hypoxanthine Phosphoribosyltransferase |
| Entry term(s) |
Guanine Phosphoribosyltransferase HGPRT HPRT HPRTase Hypoxanthine Guanine Phosphoribosyltransferase Hypoxanthine-Guanine Phosphoribosyltransferase IMP Pyrophosphorylase Phosphoribosyltransferase, Guanine Phosphoribosyltransferase, Hypoxanthine Phosphoribosyltransferase, Hypoxanthine-Guanine Pyrophosphorylase, IMP |
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