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Descriptor English: Mycophenolic Acid
Descriptor Spanish: Ácido Micofenólico
Descriptor ácido micofenólico
Scope note: Compuesto derivado del Penicillium stoloniferum, y de especies relacionadas. Bloquea la síntesis de novo de los nucleótidos de purina mediante la inhibición de la enzima inosina monofosfato deshidrogenasa (IMP DESHIDROGENASA). El ácido micofenólico ejerce efectos selectivos sobre el sistema inmunitario en el que previene la proliferación de CÉLULAS T, LINFOCITOS y la formación de anticuerpos por las CÉLULAS B. También puede inhibir el reclutamiento de LEUCOCITOS a los sitios de INFLAMACIÓN.
Descriptor Portuguese: Ácido Micofenólico
Descriptor French: Acide mycophénolique
Entry term(s): Cellcept
Mofetil Hydrochloride, Mycophenolate
Mofetil, Mycophenolate
Mycophenolate Mofetil
Mycophenolate Mofetil Hydrochloride
Mycophenolate Sodium
Mycophenolate, Sodium
Mycophenolic Acid Morpholinoethyl Ester
Myfortic
RS 61443
RS-61443
RS61443
Sodium Mycophenolate
Tree number(s): D02.241.081.193.678
D10.251.618
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D009173
Scope note: Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Antibiotics, Antitubercular
Enzyme Inhibitors
Registry Number: HU9DX48N0T
CAS Type 1 Name: -Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-
Previous Indexing: Antibiotics, Antineoplastic (1967-1971)
Caproates (1967-1971)
Public MeSH Note: 2017; MYCOPHENOLATE MOFETIL was indexed under MYCOPHENOLIC ACID 1990-2016
History Note: 2017 (1999)
DeCS ID: 9365
Unique ID: D009173
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/11
Mycophenolic Acid - Preferred
Concept UI M0014304
Scope note Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
Preferred term Mycophenolic Acid
Mycophenolate Mofetil - Narrower
Concept UI M0174120
Preferred term Mycophenolate Mofetil
Entry term(s) Mofetil, Mycophenolate
Mycophenolic Acid Morpholinoethyl Ester
Cellcept - Narrower
Concept UI M0174119
Preferred term Cellcept
Mycophenolate Sodium - Narrower
Concept UI M0556402
Preferred term Mycophenolate Sodium
Entry term(s) Mycophenolate, Sodium
Sodium Mycophenolate
Myfortic - Narrower
Concept UI M0555598
Preferred term Myfortic
Mycophenolate Mofetil Hydrochloride - Narrower
Concept UI M0443227
Preferred term Mycophenolate Mofetil Hydrochloride
Entry term(s) Mofetil Hydrochloride, Mycophenolate
RS 61443 - Narrower
Concept UI M0174122
Preferred term RS 61443
Entry term(s) RS-61443
RS61443



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