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Descriptor English: Phenylalanine Ammonia-Lyase
Descriptor Spanish: Fenilanina Amoníaco-Liasa
Descriptor fenilalanina amoniaco liasa
Scope note: Enzima que cataliza la desaminación de L-fenilalanina formándose trans-cinamato y amoniaco. También puede actuar sobre la L-tirosina. Como la enzima priva de fenilalanina al tejido neoplásico, se ha utilizado experimentalmente en el tratamiento de la leucemia linfoblástica aguda. La enzima se obtiene de muchas plantas. EC 4.3.1.5.
Descriptor Portuguese: Fenilalanina Amônia-Liase
Descriptor French: Phenylalanine ammonia-lyase
Entry term(s): Ammonia-Lyase, Phenylalanine
Ammonia-lyase, Phenylalanine-Tyrosine
Phenylalanine Ammonia Lyase
Phenylalanine Tyrosine Ammonia lyase
Phenylalanine-Tyrosine Ammonia-lyase
Tree number(s): D08.811.520.232.400.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010650
Scope note: An enzyme that catalyzes the deamination of PHENYLALANINE to form trans-cinnamate and ammonia.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.3.1.24
CAS Type 1 Name: L-Phenylalanine ammonia-lyase
Previous Indexing: Ammonia-Lyases (1973-1974)
Phenylalanine (1973-1974)
Public MeSH Note: 91; was see under AMMONIA-LYASES 1975-90
History Note: 91(75); was see under AMMONIA-LYASES 1975-90
DeCS ID: 10843
Unique ID: D010650
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/06
Phenylalanine Ammonia-Lyase - Preferred
Concept UI M0016545
Scope note An enzyme that catalyzes the deamination of PHENYLALANINE to form trans-cinnamate and ammonia.
Preferred term Phenylalanine Ammonia-Lyase
Entry term(s) Ammonia-Lyase, Phenylalanine
Phenylalanine Ammonia Lyase
Phenylalanine-Tyrosine Ammonia-lyase - Related but not broader or narrower
Concept UI M0533849
Preferred term Phenylalanine-Tyrosine Ammonia-lyase
Entry term(s) Ammonia-lyase, Phenylalanine-Tyrosine
Phenylalanine Tyrosine Ammonia lyase



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