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Descriptor English: Threonine Dehydratase
Descriptor Spanish: Treonina Deshidratasa
Descriptor treonina deshidratasa
Entry term(s) treonina desaminasa
treonina deshidrasa
Scope note: Proteína con fosfato de piridoxal que cataliza la desaminación de la TREONINA a 2-cetobutirato y AMONÍACO. El papel de esta enzima puede ser biosintético o biodegradativo. En la primera función, aporta el 2-cetobutirato requerido para la biosíntesis de ISOLEUCINA, mientras que en la segunda sólo interviene en la degradación de la treonina para proporcionar energía. Esta enzima fue listada anteriormente como EC 4.2.1.16.
Descriptor Portuguese: Treonina Desidratase
Descriptor French: Thréonine dehydratase
Entry term(s): Ammonia-Lyase, Threonine
Deaminase, Threonine
Dehydrase, Threonine
Dehydratase, Threonine
Threonine Ammonia Lyase
Threonine Ammonia-Lyase
Threonine Deaminase
Threonine Dehydrase
Tree number(s): D08.811.520.232.400.850
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013913
Scope note: A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 4.3.1.19
CAS Type 1 Name: L-Threonine hydro-lyase (deaminating)
Previous Indexing: Hydro-Lyases (1966-1974)
Threonine (1966-1974)
Public MeSH Note: 78; was see under HYDRO-LYASES 1975-77
History Note: 78(75); was see under HYDRO-LYASES 1975-77
DeCS ID: 14298
Unique ID: D013913
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30
Threonine Dehydratase - Preferred
Concept UI M0021416
Scope note A pyridoxal-phosphate protein that catalyzes the deamination of THREONINE to 2-ketobutyrate and AMMONIA. The role of this enzyme can be biosynthetic or biodegradative. In the former role it supplies 2-ketobutyrate required for ISOLEUCINE biosynthesis, while in the latter it is only involved in the breakdown of threonine to supply energy. This enzyme was formerly listed as EC 4.2.1.16.
Preferred term Threonine Dehydratase
Entry term(s) Ammonia-Lyase, Threonine
Deaminase, Threonine
Dehydrase, Threonine
Dehydratase, Threonine
Threonine Ammonia Lyase
Threonine Ammonia-Lyase
Threonine Deaminase
Threonine Dehydrase



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