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Descriptor in English: Phenytoin
Descriptor in Spanish: Fenitoína
Descriptor in Portuguese: Fenitoína
Descriptor in French: Phénytoïne
Entry term(s): 5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Antisacer
Difenin
Dihydan
Dilantin
Diphenylhydantoin
Diphenylhydantoinate, Sodium
Epamin
Epanutin
Fenitoin
Hydantol
Phenytoin Sodium
Sodium Diphenylhydantoinate
Tree number(s): D03.383.129.308.432.555.730
Scope note: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Online Note: use PHENYTOIN to search DIPHENYLHYDANTOIN 1966-77
History Note: 78; was DIPHENYLHYDANTOIN 1963-77
DeCS UI: 10867
Descriptor UI: D010672
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/06/29
Phenytoin - Preferred
Concept UI M0016580
Scope note An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Preferred term Phenytoin
Entry term(s) 5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Diphenylhydantoin
Fenitoin
Difenin - Narrower
Concept UI M0016582
Preferred term Difenin
Dihydan - Narrower
Concept UI M0016581
Preferred term Dihydan
Phenytoin Sodium - Narrower
Concept UI M0016579
Preferred term Phenytoin Sodium
Entry term(s) Diphenylhydantoinate, Sodium
Sodium Diphenylhydantoinate
Epamin - Narrower
Concept UI M0016584
Preferred term Epamin
Epanutin - Narrower
Concept UI M0353241
Preferred term Epanutin
Hydantol - Narrower
Concept UI M0016585
Preferred term Hydantol
Antisacer - Narrower
Concept UI M0353224
Preferred term Antisacer
Dilantin - Related but not broader or narrower
Concept UI M0016583
Preferred term Dilantin



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