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Descriptor English: Pimozide
Descriptor Spanish: Pimozida
Descriptor pimocida
Entry term(s) pimozida
Scope note: Difenilbutilpiperidina que es eficaz como agente antipsicótico y como alternativa al HALOPERIDOL para la supresión de tics vocales y motores en pacientes con el síndrome de Tourette. Aunque el mecanismo preciso de acción es desconocido, se ha postulado que bloquea los receptores de dopamina postsinápticos.
Descriptor Portuguese: Pimozida
Descriptor French: Pimozide
Entry term(s): Antalon
Orap
Orap forte
R-6238
R6238
Tree number(s): D03.633.100.103.732
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010868
Scope note: A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antipsychotic Agents
Dopamine Antagonists
Anti-Dyskinesia Agents
Registry Number: 1HIZ4DL86F
CAS Type 1 Name: 2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-
Previous Indexing: Benzimidazoles (1966-1972)
Tranquilizing Agents (1966-1972)
Public MeSH Note: 73
History Note: 73
DeCS ID: 11301
Unique ID: D010868
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2017/05/24
Pimozide - Preferred
Concept UI M0016871
Scope note A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Preferred term Pimozide
Antalon - Narrower
Concept UI M0474773
Preferred term Antalon
Orap - Narrower
Concept UI M0474774
Preferred term Orap
Entry term(s) Orap forte
R-6238 - Narrower
Concept UI M0353569
Preferred term R-6238
Entry term(s) R6238



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