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Descriptor English: Pyruvate Dehydrogenase Complex
Descriptor Spanish: Complejo Piruvato Deshidrogenasa
Descriptor complejo de la piruvato deshidrogenasa
Entry term(s) complejo de piruvato deshidrogenasa
Scope note: Complejo multienzimático responsable de la formación de ACETIL COENZIMA A a partir del piruvato. Las enzimas componentes son la PIRUVATO DESHIDROGENASA (LIPOAMIDA), la dihidrolipoamida acetiltransferasa y la LIPOAMIDA DESHIDROGENASA. El complejo piruvato deshidrogenasa es objeto de tres tipos de control: es inhibido por la acetil-CoA y el NADH; es influído por el estado energético de la célula; y es inhibido cuando un residuo específico de serina de la piruvato descarboxilasa es fosforilado por ATP. La PIRUVATO DESHIDROGENASA (LIPOAMIDA)-FOSFATASA cataliza la reactivación del complejo. (Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Descriptor Portuguese: Complexo Piruvato Desidrogenase
Descriptor French: Complexe du pyruvate déshydrogénase
Entry term(s): Complex, Pyruvate Dehydrogenase
Dehydrogenase Complex, Pyruvate
Tree number(s): D05.500.562.625
D08.811.600.741
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011768
Scope note: A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: deficiency:Pyruvate Dehydrogenase Complex Deficiency Disease
Previous Indexing: Oxidoreductases (1966-1972)
Pyruvate Oxidase (1966-1972)
Pyruvates (1966-1972)
Public MeSH Note: 74
History Note: 74(73)
DeCS ID: 12205
Unique ID: D011768
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2008/07/08
Pyruvate Dehydrogenase Complex - Preferred
Concept UI M0018291
Scope note A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)
Preferred term Pyruvate Dehydrogenase Complex
Entry term(s) Complex, Pyruvate Dehydrogenase
Dehydrogenase Complex, Pyruvate



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