| Descriptor English: | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase | ||||||
| Descriptor Spanish: |
5-Metiltetrahidrofolato-Homocisteína S-Metiltransferasa
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| Descriptor Portuguese: | 5-Metiltetra-Hidrofolato-Homocisteína S-Metiltransferase | ||||||
| Descriptor French: | 5-Methyltetrahydrofolate-homocysteine s-methyltransferase | ||||||
| Entry term(s): |
Homocysteine Methyltransferase, Methyltetrahydrofolate Methionine Synthase Methionine Synthetase Methyltetrahydrofolate Homocysteine Methyltransferase Methyltransferase, Methyltetrahydrofolate Homocysteine Methyltransferase, Tetrahydropteroylglutamate S-Methyltransferase, 5-Methyltetrahydrofolate-Homocysteine Synthase, Methionine Synthetase, Methionine Tetrahydropteroylglutamate Methyltransferase Vitamin B12-Dependent Methionine Synthase Vitamin B12-Independent Methionine Synthase |
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| Tree number(s): |
D08.811.913.555.500.645 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D013766 | ||||||
| Scope note: | An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13. |
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| Annotation: | /defic: consider also HOMOCYSTINURIA |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.1.1.13 | ||||||
| CAS Type 1 Name: | 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase | ||||||
| Previous Indexing: |
Methionine (1973-1974) Methyltransferases (1973-1974) Tetrahydrofolates (1973-1974) |
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| Public MeSH Note: | 98; see TETRAHYDROPTEROYLGLUTAMATE METHYLTRANSFERASE 1991-97; see METHYLTRANSFERASES 1975-90 |
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| History Note: | 98(75) |
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| Related: |
Homocystinuria
MeSH | ||||||
| DeCS ID: | 14145 | ||||||
| Unique ID: | D013766 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1974/11/19 | ||||||
| Revision Date: | 2005/06/30 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes
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5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
- Preferred
Vitamin B12-Independent Methionine Synthase
- Narrower
Vitamin B12-Dependent Methionine Synthase
- Narrower
| Concept UI |
M0021236 |
| Scope note | An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13. |
| Preferred term | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase |
| Entry term(s) |
Homocysteine Methyltransferase, Methyltetrahydrofolate Methionine Synthase Methionine Synthetase Methyltetrahydrofolate Homocysteine Methyltransferase Methyltransferase, Methyltetrahydrofolate Homocysteine Methyltransferase, Tetrahydropteroylglutamate S-Methyltransferase, 5-Methyltetrahydrofolate-Homocysteine Synthase, Methionine Synthetase, Methionine Tetrahydropteroylglutamate Methyltransferase |
| Concept UI |
M0021238 |
| Preferred term | Vitamin B12-Independent Methionine Synthase |
| Concept UI |
M0021237 |
| Preferred term | Vitamin B12-Dependent Methionine Synthase |
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