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Descriptor English: Thymidylate Synthase
Descriptor Spanish: Timidilato Sintasa
Descriptor timidilato sintasa
Scope note: Enzima de la clase transferasas que cataliza la reacción de 5,10-metilenotetrahidrofolato y dUMP a dihidrofolato y dTMP en la síntesis de trifosfato de timidina. (Dorland, 27th ed) EC 2.1.1.45.
Descriptor Portuguese: Timidilato Sintase
Descriptor French: Thymidylate synthase
Entry term(s): Synthase, Thymidylate
Synthetase, Thymidylate
Thymidylate Synthetase
Tree number(s): D08.811.913.555.500.862
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013940
Scope note: An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.1.1.45
CAS Type 1 Name: 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
Previous Indexing: Ligases (1966-1970)
Methyltransferases (1971-1972)
Transferases (1969-1972)
Public MeSH Note: 98(86); see METHYLTRANSFERASES 1975-85, see THYMIDYLATE SYNTHETASE 1985-97
History Note: 98; see METHYLTRANSFERASES 1975-85
DeCS ID: 14327
Unique ID: D013940
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1986/01/01
Date of Entry: 1999/01/01
Revision Date: 2003/07/09
Thymidylate Synthase - Preferred
Concept UI M0021454
Scope note An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
Preferred term Thymidylate Synthase
Entry term(s) Synthase, Thymidylate
Synthetase, Thymidylate
Thymidylate Synthetase



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