Search
Descriptor English: Uncoupling Agents
Descriptor Spanish: Desacopladores
Descriptor desacopladores
Entry term(s) agentes desacopladores
desacoplantes
Scope note: Sustancias químicas que desacoplan la oxidación de la fosforilación en el ciclo metabólico, de manera que no tiene lugar la síntesis de ATP. Pertenecen a esta clase aquellos IONÓFOROS que bloquean la transferencia de electrones creando un cortocircuito en el gradiente de protones a través de las membranas mitocondriales.
Descriptor Portuguese: Desacopladores
Descriptor French: Agents découplants
Entry term(s): Agents, Uncoupling
Tree number(s): D27.505.519.389.936
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014475
Scope note: Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
Annotation: enzyme inhib
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Oxidative Phosphorylation/drug effects (1966-1968)
Oxidoreductases/antagonists & inhibitors (1968)
Public MeSH Note: 72; DIO-9 was see under ANTIBIOTICS 1975-81
History Note: 72(69)
Related: Ionophores MeSH
DeCS ID: 14874
Unique ID: D014475
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2014/06/25
Uncoupling Agents - Preferred
Concept UI M0022252
Scope note Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes.
Preferred term Uncoupling Agents
Entry term(s) Agents, Uncoupling



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey