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Descriptor English: Gamma Secretase Inhibitors and Modulators
Descriptor Spanish: Inhibidores y Moduladores de Gamma Secretasa
Descriptor inhibidores y moduladores de la gamma-secretasa
Entry term(s) inhibidores de la GS
inhibidores de la gamma-secretasa
inhibidores y moduladores de la GS
moduladores de la GS
moduladores de la gamma-secretasa
Scope note: Agentes que suprimen la gamma-secretasa inhibiendo o modulando sus actividades. Las actividades enzimáticas dirigidas incluyen su participación en la acumulación de PÉPTIDOS AMILOIDES BETA tóxicos (por ejemplo, Aβ42) en la ENFERMEDAD DE ALZHEIMER y la activación de VÍAS DE TRANSDUCCIÓN DE SEÑALES mediadas por RECEPTORES NOTCH en ciertos tipos de cáncer.
Descriptor Portuguese: Inibidores e Moduladores de Secretases gama
Descriptor French: Without translation
Entry term(s): GS Inhibitors
GS Inhibitors and Modulators
GS Modulators
Gamma Secretase Inhibitors
Gamma Secretase Modulators
Secretase Inhibitors, Gamma
Secretase Modulators, Gamma
Tree number(s): D27.505.519.389.315
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000091062
Scope note: Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Previous Indexing: Amyloid Precursor Protein Secretases (1995-2021)
Public MeSH Note: 2022
History Note: 2022
DeCS ID: 59835
Unique ID: D000091062
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2022/01/01
Date of Entry: 2021/07/09
Revision Date: 2021/06/30
Gamma Secretase Inhibitors and Modulators - Preferred
Concept UI M000747845
Scope note Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.
Preferred term Gamma Secretase Inhibitors and Modulators
Entry term(s) GS Inhibitors and Modulators
Gamma Secretase Modulators - Narrower
Concept UI M000747847
Preferred term Gamma Secretase Modulators
Entry term(s) GS Modulators
Secretase Modulators, Gamma
Gamma Secretase Inhibitors - Narrower
Concept UI M000747846
Preferred term Gamma Secretase Inhibitors
Entry term(s) GS Inhibitors
Secretase Inhibitors, Gamma



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