CHEMICALS AND DRUGS Chemical Actions and Uses [D27] Chemical Actions and Uses Pharmacologic Actions [D27.505] Pharmacologic Actions Molecular Mechanisms of Pharmacological Action [D27.505.519] Molecular Mechanisms of Pharmacological Action Enzyme Inhibitors [D27.505.519.389] Enzyme Inhibitors 5-Lipoxygenase-Activating Protein Inhibitors [D27.505.519.389.086] 5-Lipoxygenase-Activating Protein Inhibitors Acetaldehyde Dehydrogenase Inhibitors [D27.505.519.389.089] Acetaldehyde Dehydrogenase Inhibitors Adenosine Deaminase Inhibitors [D27.505.519.389.092] Adenosine Deaminase Inhibitors Adenylyl Cyclase Inhibitors [D27.505.519.389.108] Adenylyl Cyclase Inhibitors Aromatic Amino Acid Decarboxylase Inhibitors [D27.505.519.389.124] Aromatic Amino Acid Decarboxylase Inhibitors Calcineurin Inhibitors [D27.505.519.389.174] Calcineurin Inhibitors Carbonic Anhydrase Inhibitors [D27.505.519.389.200] Carbonic Anhydrase Inhibitors Catechol O-Methyltransferase Inhibitors [D27.505.519.389.237] Catechol O-Methyltransferase Inhibitors Cholinesterase Inhibitors [D27.505.519.389.275] Cholinesterase Inhibitors Cyclooxygenase Inhibitors [D27.505.519.389.310] Cyclooxygenase Inhibitors Gamma Secretase Inhibitors and Modulators [D27.505.519.389.315] Gamma Secretase Inhibitors and Modulators Glycoside Hydrolase Inhibitors [D27.505.519.389.320] Glycoside Hydrolase Inhibitors Cytochrome P-450 Enzyme Inhibitors [D27.505.519.389.335] Cytochrome P-450 Enzyme Inhibitors Folic Acid Antagonists [D27.505.519.389.350] Folic Acid Antagonists Histone Deacetylase Inhibitors [D27.505.519.389.360] Histone Deacetylase Inhibitors Hydroxymethylglutaryl-CoA Reductase Inhibitors [D27.505.519.389.370] Hydroxymethylglutaryl-CoA Reductase Inhibitors Integrase Inhibitors [D27.505.519.389.375] Integrase Inhibitors beta-Lactamase Inhibitors [D27.505.519.389.400] beta-Lactamase Inhibitors Lipoxygenase Inhibitors [D27.505.519.389.480] Lipoxygenase Inhibitors Monoamine Oxidase Inhibitors [D27.505.519.389.616] Monoamine Oxidase Inhibitors Nucleic Acid Synthesis Inhibitors [D27.505.519.389.675] Nucleic Acid Synthesis Inhibitors Ornithine Decarboxylase Inhibitors [D27.505.519.389.705] Ornithine Decarboxylase Inhibitors Phosphodiesterase Inhibitors [D27.505.519.389.735] Phosphodiesterase Inhibitors Phosphoinositide-3 Kinase Inhibitors [D27.505.519.389.736] Phosphoinositide-3 Kinase Inhibitors Phospholipase A2 Inhibitors [D27.505.519.389.737] Phospholipase A2 Inhibitors Poly(ADP-ribose) Polymerase Inhibitors [D27.505.519.389.739] Poly(ADP-ribose) Polymerase Inhibitors Prolyl-Hydroxylase Inhibitors [D27.505.519.389.740] Prolyl-Hydroxylase Inhibitors Protease Inhibitors [D27.505.519.389.745] Protease Inhibitors Protein Kinase Inhibitors [D27.505.519.389.755] Protein Kinase Inhibitors Protein Synthesis Inhibitors [D27.505.519.389.760] Protein Synthesis Inhibitors Proton Pump Inhibitors [D27.505.519.389.848] Proton Pump Inhibitors Steroid Synthesis Inhibitors [D27.505.519.389.870] Steroid Synthesis Inhibitors Topoisomerase Inhibitors [D27.505.519.389.892] Topoisomerase Inhibitors Uncoupling Agents [D27.505.519.389.936] Uncoupling Agents

Gamma Secretase Inhibitors and Modulators - Preferred

Concept UI	M000747845
Scope note	Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.
Preferred term	Gamma Secretase Inhibitors and Modulators
Entry term(s)	GS Inhibitors and Modulators

Gamma Secretase Modulators - Narrower

Concept UI	M000747847
Preferred term	Gamma Secretase Modulators
Entry term(s)	GS Modulators Secretase Modulators, Gamma

Gamma Secretase Inhibitors - Narrower

Concept UI	M000747846
Preferred term	Gamma Secretase Inhibitors
Entry term(s)	GS Inhibitors Secretase Inhibitors, Gamma