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Descriptor English: Arachidonate 12-Lipoxygenase
Descriptor Spanish: Araquidonato 12-Lipooxigenasa
Descriptor araquidonato 12-lipooxigenasa
Entry term(s) 12-lipooxigenasa
Scope note: Enzima que cataliza la oxidación del ácido araquidónico para formar 12-hidroperoxiaraquidonato (12-HPETE), el cual es rápidamente convertido por una peroxidasa en 12-hidroxi-5,8,10,14-eicosatetraenoato (12-HETE). Los 12-hidroperóxidos se forman preferentemente en las plaquetas. EC 1.13.11.31.
Descriptor Portuguese: Araquidonato 12-Lipoxigenase
Descriptor French: Arachidonate 12-lipoxygenase
Entry term(s): 12 Lipoxygenase
12-Lipoxygenase
12-Lipoxygenase, Arachidonate
12-Lipoxygenase, Arachidonic Acid
Arachidonate 12 Lipoxygenase
Arachidonic Acid 12 Lipoxygenase
Arachidonic Acid 12-Lipoxygenase
Tree number(s): D08.811.682.690.416.583.500.060
D12.776.556.579.374.568.500.025
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D001092
Scope note: An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Lipoxygenase Inhibitors
Registry Number: EC 1.13.11.31
CAS Type 1 Name: Arachidonate:oxygen 12-oxidoreductase
Previous Indexing: Lipoxygenases (1974-1986)
Oxygenases (1966-1973)
Public MeSH Note: 91; was see under ARACHIDONATE LIPOXYGENASES 1987-90
History Note: 91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
DeCS ID: 19075
Unique ID: D001092
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1986/06/16
Revision Date: 2010/06/25
Arachidonate 12-Lipoxygenase - Preferred
Concept UI M0001646
Scope note An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Preferred term Arachidonate 12-Lipoxygenase
Entry term(s) 12 Lipoxygenase
12-Lipoxygenase
12-Lipoxygenase, Arachidonate
12-Lipoxygenase, Arachidonic Acid
Arachidonate 12 Lipoxygenase
Arachidonic Acid 12 Lipoxygenase
Arachidonic Acid 12-Lipoxygenase



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