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Descriptor English: Pirenzepine
Descriptor Spanish: Pirenzepina
Descriptor pirencepina
Entry term(s) pirenzepina
Scope note: Agente antimuscarínico que inhibe la secreción gástrica a dosis más bajas que las requeridas para afectar la motilidad gastrointestinal, la función salivar, el sistema nervioso central, cardiovascular, ocular y urinario. Promueve la cicatrización de la úlcera duodenal y, debido a su acción citoprotectora, es beneficioso en la prevención de la recurrencia de la úlcera duodenal. Potencia también el efecto de otros agentes antiulcerosos tales como CIMETIDINA y RANITIDINA. Suele tener una buena tolerancia.
Descriptor Portuguese: Pirenzepina
Descriptor French: Pirenzépine
Entry term(s): Dihydrochloride, Pirenzepine
Gastrotsepin
Gastrozepin
L-S 519
LS 519
LS-519
LS519
Piren Basan
Piren-Basan
Pirenzepin
Pirenzepin Ratiopharm
Pirenzepin Von Ct
Pirenzepin-Ratiopharm
Pirenzepine Dihydrochloride
Pyrenzepine
Ulcoprotect
Ulgescum
Von Ct, Pirenzepin
Tree number(s): D03.633.100.079.080.070.750
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010890
Scope note: An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Anti-Ulcer Agents
Muscarinic Antagonists
Registry Number: 3G0285N20N
CAS Type 1 Name: 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-
Previous Indexing: Azepines (1966-1973)
Benzodiazepinones (1974-1986)
Public MeSH Note: 87
History Note: 87
DeCS ID: 19292
Unique ID: D010890
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/04/09
Revision Date: 2017/05/24
Pirenzepine - Preferred
Concept UI M0016894
Scope note An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as CIMETIDINE and RANITIDINE. It is generally well tolerated by patients.
Preferred term Pirenzepine
Entry term(s) Pirenzepin
Pyrenzepine
L-S 519 - Narrower
Concept UI M0353490
Preferred term L-S 519
Entry term(s) LS 519
LS-519
LS519
Pirenzepine Dihydrochloride - Narrower
Concept UI M0475054
Preferred term Pirenzepine Dihydrochloride
Entry term(s) Dihydrochloride, Pirenzepine
Gastrozepin - Narrower
Concept UI M0016895
Preferred term Gastrozepin
Ulgescum - Narrower
Concept UI M0475056
Preferred term Ulgescum
Piren-Basan - Narrower
Concept UI M0475057
Preferred term Piren-Basan
Entry term(s) Piren Basan
Pirenzepin Von Ct - Narrower
Concept UI M0475058
Preferred term Pirenzepin Von Ct
Entry term(s) Von Ct, Pirenzepin
Pirenzepin-Ratiopharm - Narrower
Concept UI M0475059
Preferred term Pirenzepin-Ratiopharm
Entry term(s) Pirenzepin Ratiopharm
Gastrotsepin - Narrower
Concept UI M0475053
Preferred term Gastrotsepin
Ulcoprotect - Narrower
Concept UI M0475055
Preferred term Ulcoprotect



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