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Descriptor English: Anthramycin
Descriptor Spanish: Antramicina
Descriptor antramicina
Scope note: Antibiótico antineoplásico de ámplio espectro, aislado a partir del Streptomyces refuineus var. termoetable. Posee baja toxicidad, alguna actividad frente a tricomonas y Endamoeba, e inhibe la síntesis de ARN y ADN. Se une irreversiblemente al ADN.
Descriptor Portuguese: Antramicina
Descriptor French: Antramycine
Entry term(s): Anthramycin, (11a alpha)-Isomer
Antramycin
Tree number(s): D03.633.100.079.080.070.050
D03.633.300.060
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000876
Scope note: A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antibiotics, Antineoplastic
Registry Number: 0WZD9Y66WN
CAS Type 1 Name: 2-Propenamide, 3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1H-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-, (11R-(2(E),11alpha,11abeta))-
Previous Indexing: Acrylamides (1973-1974)
Benzodiazepinones (1974)
Pyrroles (1972-1974)
Public MeSH Note: 91; was see under BENZODIAZEPINONES 1975-90
History Note: 91(75); was see under BENZODIAZEPINONES 1975-90
DeCS ID: 891
Unique ID: D000876
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2016/05/27
Anthramycin - Preferred
Concept UI M0001309
Scope note A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.
Preferred term Anthramycin
Entry term(s) Antramycin
Anthramycin, (11a alpha)-Isomer - Narrower
Concept UI M0330779
Preferred term Anthramycin, (11a alpha)-Isomer



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