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Descriptor English: Buprenorphine
Descriptor Spanish: Buprenorfina
Descriptor Portuguese: Buprenorfina
Descriptor French: Buprénorphine
Entry term(s): 6029 M
6029-M
6029M
Buprenex
Buprenorphine Hydrochloride
Buprex
Hydrochloride, Buprenorphine
Prefin
RX 6029 M
RX-6029-M
RX6029M
Subutex
Temgesic
Temgésic
Tree number(s): D03.132.577.249.150
D03.605.497.150
D03.633.400.686.150
D04.615.723.795.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002047
Scope note: A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Annotation: for buprenorphine maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Analgesics, Opioid
Narcotic Antagonists
Narcotics
Registry Number: 40D3SCR4GZ
CAS Type 1 Name: 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-
Previous Indexing: Dihydromorphinone (1966-1968)
Morphinans (1969-1978)
Morphine (1966-1968)
Public MeSH Note: 87; was see under MORPHINANS 1979-86
History Note: 87(79); was see under MORPHINANS 1979-86
Related: Opiate Substitution Treatment MeSH
DeCS ID: 2079
Unique ID: D002047
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1978/03/17
Revision Date: 2017/05/24
Buprenorphine - Preferred
Concept UI M0003054
Scope note A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Preferred term Buprenorphine
Buprenex - Narrower
Concept UI M0352882
Preferred term Buprenex
Prefin - Narrower
Concept UI M0465414
Preferred term Prefin
Subutex - Narrower
Concept UI M0003053
Preferred term Subutex
Entry term(s) Buprex
Temgesic
Temgésic
6029-M - Narrower
Concept UI M0352881
Preferred term 6029-M
Entry term(s) 6029 M
6029M
RX 6029 M
RX-6029-M
RX6029M
Buprenorphine Hydrochloride - Narrower
Concept UI M0330887
Preferred term Buprenorphine Hydrochloride
Entry term(s) Hydrochloride, Buprenorphine



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