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Descriptor English: Levallorphan
Descriptor Spanish: Levalorfano
Descriptor levalorfano
Entry term(s) naloxifan
naloxifano
Scope note: Antagonista de los opioides, con propiedades similares a las de la NALOXONA; también posee algunas propiedades agonistas. Debe utilizarse con cautela pues aunque el levalorfano revierte la depresión respiratoria intensa inducida por los opioides, sin embargo puede exacerbar depresiones respiratorias como la inducida por alcohol y otro depresores del SNC no opioides.
Descriptor Portuguese: Levalorfano
Descriptor French: Lévallorphane
Entry term(s): Lorfan
Naloxiphan
Tree number(s): D03.132.577.249.413
D03.605.497.429
D03.633.400.686.429
D04.615.723.795.413
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007977
Scope note: An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Narcotic Antagonists
Registry Number: 353613BU4U
CAS Type 1 Name: Morphinan-3-ol, 17-(2-propenyl)-
Public MeSH Note: 65; was see under NARCOTIC ANTAGONISTS 1963-64
History Note: 65; was see under NARCOTIC ANTAGONISTS 1963-64
DeCS ID: 8153
Unique ID: D007977
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Levallorphan - Preferred
Concept UI M0012429
Scope note An opioid antagonist with properties similar to those of NALOXONE; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
Preferred term Levallorphan
Entry term(s) Naloxiphan
Lorfan - Narrower
Concept UI M0012430
Preferred term Lorfan



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