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Descriptor English: Dextromethorphan
Descriptor Spanish: Dextrometorfano
Descriptor dextrometorfano
Entry term(s) d-metorfan
Scope note: Análogo metilado del DEXTRORFANO que muestra una elevada afinidad para unirse en determinadas regiones del encéfalo, incluido el centro medular de la tos. Este compuesto es antagonista del receptor NMDA (RECEPTORES DE N-METIL-D-ASPARTATO) y actúa como bloqueante de canales no competitivo. Es uno de los ANTITUSIVOS más utilizados, y también se usa para el estudio del papel de los receptores de glutamato en neurotoxicidad.
Descriptor Portuguese: Dextrometorfano
Descriptor French: Dextrométhorphane
Entry term(s): Delsym
Dextromethorphan Hydrobromide
Dextromethorphan Hydrobromide, (+-)-Isomer
Dextromethorphan Hydrobromide, Monohydrate
Dextromethorphan Hydrochloride
Dextromethorphan, (+-)-Isomer
Hydrobromide, Dextromethorphan
Hydrochloride, Dextromethorphan
Racemethorphan
d-Methorphan
Tree number(s): D03.132.577.249.200
D03.605.497.212
D03.633.400.686.212
D04.615.723.795.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003915
Scope note: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antitussive Agents
Excitatory Amino Acid Antagonists
Registry Number: 7355X3ROTS
CAS Type 1 Name: Morphinan, 3-methoxy-17-methyl-, (9alpha,13alpha,14alpha)-
Previous Indexing: Antitussive Agents (1966-1971)
Morphinans (1969-1971)
Public MeSH Note: 91; was see under LEVORPHANOL 1972-90
History Note: 91(72); was see under LEVORPHANOL 1972-90
DeCS ID: 3936
Unique ID: D003915
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/29
Dextromethorphan - Preferred
Concept UI M0006138
Scope note Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.
Preferred term Dextromethorphan
Entry term(s) d-Methorphan
Dextromethorphan, (+-)-Isomer - Related but not broader or narrower
Concept UI M0330520
Preferred term Dextromethorphan, (+-)-Isomer
Dextromethorphan Hydrobromide, Monohydrate - Narrower
Concept UI M0330522
Preferred term Dextromethorphan Hydrobromide, Monohydrate
Delsym - Narrower
Concept UI M0006137
Preferred term Delsym
Dextromethorphan Hydrobromide - Narrower
Concept UI M0330518
Preferred term Dextromethorphan Hydrobromide
Entry term(s) Hydrobromide, Dextromethorphan
Dextromethorphan Hydrobromide, (+-)-Isomer - Related but not broader or narrower
Concept UI M0330521
Preferred term Dextromethorphan Hydrobromide, (+-)-Isomer
Dextromethorphan Hydrochloride - Narrower
Concept UI M0330519
Preferred term Dextromethorphan Hydrochloride
Entry term(s) Hydrochloride, Dextromethorphan
Racemethorphan - Broader
Concept UI M0006140
Preferred term Racemethorphan



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