| Descriptor English: | Sex Hormone-Binding Globulin | ||||||
| Descriptor Spanish: |
Globulina de Unión a Hormona Sexual
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| Descriptor Portuguese: | Globulina de Ligação a Hormônio Sexual | ||||||
| Descriptor French: | Globuline de liaison aux hormones sexuelles | ||||||
| Entry term(s): |
Binding Globulin, Testosterone-Estradiol Globulin, Sex Hormone-Binding Globulin, Testosterone-Estradiol Binding Hormone-Binding Globulin, Sex Sex Hormone Binding Globulin Sex Steroid Binding Protein Sex Steroid-Binding Protein Steroid-Binding Protein, Sex Testosterone Estradiol Binding Globulin Testosterone-Estradiol Binding Globulin |
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| Tree number(s): |
D12.776.124.790.223.800 D12.776.157.762 D12.776.377.715.182.800 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D012738 | ||||||
| Scope note: | A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications. |
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| Annotation: | does not refer to all sex hormones: refers to a specific protein in the blood binding only testosterone or estradiol; for other sex hormone-binding globulins consider ANDROGEN-BINDING PROTEIN & PROGESTERONE-BINDING GLOBULIN; DF: SHBG |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Beta Globulins (1974-1976) Carrier Proteins (1971-1991) Glycoproteins (1974-1975) Protein Binding (1974-1975) Sex Hormones (1974-1976) |
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| Public MeSH Note: | 77; SEX-STEROID-BINDING PROTEIN was indexed under CARRIER PROTEINS 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92 |
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| Online Note: | use SEX HORMONE-BINDING GLOBULIN (NM) to search SEX-STEROID-BINDING PROTEIN 1981-91; use SEX HORMONE-BINDING GLOBULIN to search ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN 1977-92 |
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| History Note: | 77; SEX STEROID-BINDING PROTEIN was SEX-STEROID-BINDING PROTEIN (NM) 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92 |
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| Entry Version: | SHBG |
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| Related: |
Androgen-Binding Protein
MeSH | ||||||
| DeCS ID: | 22292 | ||||||
| Unique ID: | D012738 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1977/01/01 | ||||||
| Date of Entry: | 1976/04/16 | ||||||
| Revision Date: | 2004/08/02 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Sex Hormone-Binding Globulin
- Preferred
| Concept UI |
M0019743 |
| Scope note | A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications. |
| Preferred term | Sex Hormone-Binding Globulin |
| Entry term(s) |
Binding Globulin, Testosterone-Estradiol Globulin, Sex Hormone-Binding Globulin, Testosterone-Estradiol Binding Hormone-Binding Globulin, Sex Sex Hormone Binding Globulin Sex Steroid Binding Protein Sex Steroid-Binding Protein Steroid-Binding Protein, Sex Testosterone Estradiol Binding Globulin Testosterone-Estradiol Binding Globulin |
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