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Descriptor English: Pancreatic Polypeptide
Descriptor Spanish: Polipéptido Pancreático
Descriptor polipéptido pancreático
Scope note: Hormona pancreática de 36 aminoácidos que es segregada principalmente por células endocrinas que se encuentran en la periferia de los ISLOTES DE LANGERHANS y adyacentes a células que contienen SOMATOSTATINA y GLUCAGÓN. El polipéptido pancreático (PP), cuando se administra periféricamente, puede inhibir la secreción gástrica, el vaciamiento gástrico, la secreción de enzimas pancreáticas y el apetito. La ausencia de polipéptido pancreático se ha asociado a la OBESIDAD en ratas y ratones.
Descriptor Portuguese: Polipeptídeo Pancreático
Descriptor French: Polypeptide pancréatique
Entry term(s): Pancreatic Polypeptide (PP)
Pancreatic Polypeptide Hormone
Pancreatic Prohormone
Tree number(s): D06.472.699.587.700
D12.644.400.600
D12.644.548.586.700
D12.776.631.650.600
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010191
Scope note: A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Gastrointestinal Agents
Hormones
Registry Number: 59763-91-6
Previous Indexing: Hormones (1966-1973)
Pancreatic Hormones (1974-1978)
Peptides (1966-1978)
Public MeSH Note: 79
History Note: 79
DeCS ID: 22598
Unique ID: D010191
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1979/01/01
Date of Entry: 1978/05/18
Revision Date: 2015/11/24
Pancreatic Polypeptide - Preferred
Concept UI M0015804
Scope note A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Preferred term Pancreatic Polypeptide
Entry term(s) Pancreatic Polypeptide (PP)
Pancreatic Polypeptide Hormone
Pancreatic Prohormone - Broader
Concept UI M0496467
Scope note A secreted polypeptide of about 100 amino acids, depending on the species, from the PANCREASE. It is the precursor of pancreatic polypeptide (PP) and a pancreatic C-terminal peptide or pancreatic icosapeptide.
Preferred term Pancreatic Prohormone



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