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Descriptor English: omega-Agatoxin IVA
Descriptor Spanish: omega-Agatoxina IVA
Descriptor omega-agatoxina IVA
Entry term(s) omega-aga-IVA
Scope note: Neuropéptido que es una toxina del veneno de la araña de tela en embudo, Agelenopsis aperta. Inhibe los CANALES DEL CALCIO TIPO P al alterar la apertura dependiente del voltaje, de modo que se necesita una gran despolarización para abrir el canal. También inhibe los CANALES DEL CALCIO TIPO Q.
Descriptor Portuguese: ômega-Agatoxina IVA
Descriptor French: Agatoxine-oméga-IVA
Entry term(s): IVA, omega-Agatoxin
omega Aga IVA
omega Agatoxin IVA
omega-Aga-IVA
Tree number(s): D12.644.400.562
D12.776.093.249.500
D20.888.065.870.324.500
D23.946.833.065.870.324.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020867
Scope note: A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
EN enzymology
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Calcium Channel Blockers
Neurotoxins
Previous Indexing: Spider Venoms (1992-1999)
Public MeSH Note: 2000; OMEGA-AGATOXIN IVA was indexed under SPIDER VENOMS 1992-1999
History Note: 2000; use OMEGA-AGATOXIN IVA (NM) 1992-1999
DeCS ID: 34517
Unique ID: D020867
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2015/06/18
omega-Agatoxin IVA - Preferred
Concept UI M0328342
Scope note A neuropeptide toxin from the venom of the funnel web spider, Agelenopsis aperta. It inhibits CALCIUM CHANNELS, P-TYPE by altering the voltage-dependent gating so that very large depolarizations are needed for channel opening. It also inhibits CALCIUM CHANNELS, Q-TYPE.
Preferred term omega-Agatoxin IVA
Entry term(s) IVA, omega-Agatoxin
omega Aga IVA
omega Agatoxin IVA
omega-Aga-IVA



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