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Descriptor English: Tissue Distribution
Descriptor Spanish: Distribución Tisular
Descriptor distribución tisular
Scope note: Acumulación de una droga o de una sustancia química en diversos órganos (incluidos aquellos que no son relevantes en cuanto a su acción farmacológica o terapéutica). Esta distribución depende del flujo de sangre o la tasa de perfusión del órgano, de la capacidad de la droga para penetrar las membranas del órgano, de la especificidad del tejido y de la unión a proteínas. La distribución generalmente se expresa como una relación plasma-tejido.
Descriptor Portuguese: Distribuição Tecidual
Descriptor French: Distribution tissulaire
Entry term(s): Distribution, Tissue
Distributions, Tissue
Tissue Distributions
Tree number(s): G03.787.917
G07.690.725.949
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D014018
Scope note: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Annotation: general only: not a substitute for organ /metab or organ /chem; usually NIM; coordinate with substance /pharmacokin or /metab
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Organ Specificity (1966-1977)
Public MeSH Note: 78
History Note: 78
DeCS ID: 23482
Unique ID: D014018
NLM Classification: QV 38
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/04/27
Revision Date: 2016/07/01
Tissue Distribution - Preferred
Concept UI M0021578
Scope note Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Preferred term Tissue Distribution
Entry term(s) Distribution, Tissue
Distributions, Tissue
Tissue Distributions



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