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Descriptor English: Deoxyribonucleases, Type I Site-Specific
Descriptor Spanish: Desoxirribonucleasas de Localización Especificada Tipo I
Descriptor desoxirribonucleasas específicas del sitio de tipo I
Entry term(s) DNasa específica del sitio de tipo I
desoxirribonucleasas sitio-específicas tipo I
endonucleasas de restricción de tipo I
enzimas de restricción de tipo I
enzimas de restricción del ADN de tipo I
Scope note: Sistemas enzimáticos que contienen tres subunidades diferentes y que requieren ATP, S-adenosilmetionina y magnesio para su actividad endonucleolítica para producir fragmentos bicatenarios al azar con 5'-fosfatos terminales. Funcionan también como ATPasas dependientes del ADN y como metilasas de modificación, catalizando las reacciones de EC 2.1.1.72 y EC 2.2.2.73 con similar especificidad por el sitio. Los sistemas reconocen secuencias específicas cortas del ADN y escinden en sitios que están lejos de la secuencia de reconocimiento. Las enzimas de diferentes microorganismos con la misma especificidad se denominan isoesquizómeros. EC 3.1.21.3.
Descriptor Portuguese: Desoxirribonucleases de Sítio Específico do Tipo I
Descriptor French: Type I site-specific deoxyribonuclease
Entry term(s): DNA Restriction Enzymes, Type I
DNase, Site Specific, Type I
DNase, Site-Specific, Type I
Deoxyribonucleases, Type I Site Specific
Deoxyribonucleases, Type I, Site Specific
Deoxyribonucleases, Type I, Site-Specific
Restriction Endonucleases, Type I
Site Specific DNase, Type I
Site-Specific DNase, Type I
Type I Restriction Enzymes
Type I Site Specific DNase
Type I Site Specific Deoxyribonucleases
Type I Site-Specific DNase
Type I Site-Specific Deoxyribonucleases
Tree number(s): D08.811.150.280.250
D08.811.277.352.335.350.300.250
D08.811.277.352.355.325.300.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015253
Scope note: Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.21.3
Previous Indexing: DNA Restriction Enzymes (1978-1988)
Public MeSH Note: 89
History Note: 89
Entry Version: DNASE SS I
DeCS ID: 23602
Unique ID: D015253
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/17
Revision Date: 2003/07/09
Deoxyribonucleases, Type I Site-Specific - Preferred
Concept UI M0023491
Scope note Enzyme systems containing three different subunits and requiring ATP, S-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent ATPases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.3.
Preferred term Deoxyribonucleases, Type I Site-Specific
Entry term(s) DNA Restriction Enzymes, Type I
DNase, Site Specific, Type I
DNase, Site-Specific, Type I
Deoxyribonucleases, Type I Site Specific
Deoxyribonucleases, Type I, Site Specific
Deoxyribonucleases, Type I, Site-Specific
Restriction Endonucleases, Type I
Site Specific DNase, Type I
Site-Specific DNase, Type I
Type I Restriction Enzymes
Type I Site Specific DNase
Type I Site Specific Deoxyribonucleases
Type I Site-Specific DNase
Type I Site-Specific Deoxyribonucleases



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