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Descriptor English: Deoxyribonucleases, Type III Site-Specific
Descriptor Spanish: Desoxirribonucleasas de Localización Especificada Tipo III
Descriptor desoxirribonucleasas específicas del sitio de tipo III
Entry term(s) DNasa específica del sitio de tipo III
desoxirribonucleasas sitio-específicas tipo III
endonucleasas de restricción de tipo III
enzimas de restricción de tipo III
enzimas de restricción del ADN de tipo III
Scope note: Sistemas enzimáticos compuestos de dos subunidades que requieren ATP y magnesio para su actividad endonucleolítica. No funcionan como ATPasas. Existen como complejos con metilasas de modificación de especifidad similar listada bajo EC 2.1.1.72 o EC 2.1.1.73. Los sistemas reconocen secuencias cortas específicas de ADN y se rompen a poca distancia, aproximadamente a 24 a 27 bases de la secuencia de reconocimiento, para producir fragmentos de doble cadena con 5'-fosfatos terminales. Enzimas de diferentes microorganismos con la misma especificidad se denominan isosquizómeros. EC 3.1.21.5.
Descriptor Portuguese: Desoxirribonucleases de Sítio Específico do Tipo III
Descriptor French: Type III site-specific deoxyribonuclease
Entry term(s): DNA Restriction Enzymes, Type III
DNase, Site Specific, Type III
DNase, Site-Specific, Type III
Deoxyribonucleases, Type III Site Specific
Deoxyribonucleases, Type III, Site Specific
Deoxyribonucleases, Type III, Site-Specific
Restriction Endonucleases, Type III
Site Specific DNase, Type III
Site-Specific DNase, Type III
Type III Restriction Enzymes
Type III Site Specific DNase
Type III Site Specific Deoxyribonucleases
Type III Site-Specific DNase
Type III Site-Specific Deoxyribonucleases
Tree number(s): D08.811.150.280.270
D08.811.277.352.335.350.300.270
D08.811.277.352.355.325.300.270
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015263
Scope note: Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as ATPases. They exist as complexes with modification methylases of similar specificity listed under EC 2.1.1.72 or EC 2.1.1.73. The systems recognize specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.5.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.1.21.5
Previous Indexing: DNA Restriction Enzymes (1975-1988)
Public MeSH Note: 89
History Note: 89
Entry Version: DNASE SS III
DeCS ID: 23604
Unique ID: D015263
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/18
Revision Date: 2003/07/09
Deoxyribonucleases, Type III Site-Specific - Preferred
Concept UI M0023503
Scope note Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as ATPases. They exist as complexes with modification methylases of similar specificity listed under EC 2.1.1.72 or EC 2.1.1.73. The systems recognize specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.5.
Preferred term Deoxyribonucleases, Type III Site-Specific
Entry term(s) DNA Restriction Enzymes, Type III
DNase, Site Specific, Type III
DNase, Site-Specific, Type III
Deoxyribonucleases, Type III Site Specific
Deoxyribonucleases, Type III, Site Specific
Deoxyribonucleases, Type III, Site-Specific
Restriction Endonucleases, Type III
Site Specific DNase, Type III
Site-Specific DNase, Type III
Type III Restriction Enzymes
Type III Site Specific DNase
Type III Site Specific Deoxyribonucleases
Type III Site-Specific DNase
Type III Site-Specific Deoxyribonucleases



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