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Descriptor English: Dideoxynucleosides
Descriptor Spanish: Didesoxinucleósidos
Descriptor didesoxinucleósidos
Entry term(s) 2',3'-didesoxinucleósidos
didesoxirribonucleósidos
Scope note: Nucleósidos que no tienen dos grupos hidroxilos en la molécula de azúcar. La mayoría de estos compuestos tienen una actividad antirretrovírica de amplio espectro debido a su acción como antimetabolitos. Los nucleósidos se fosforilan intracelularmente a sus 5'-trifosfatos y actúan como inhibidores de la terminación de la cadena en la transcripción inversa vírica.
Descriptor Portuguese: Didesoxinucleosídeos
Descriptor French: Didéoxynucléosides
Entry term(s): 2',3' Dideoxynucleosides
2',3'-Dideoxynucleosides
Dideoxyribonucleosides
ddNus
Tree number(s): D13.570.230.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015224
Scope note: Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Annotation: antivirals & antimetabolites
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors
Previous Indexing: Deoxyribonucleosides (1971-1988)
Public MeSH Note: 89
History Note: 89
DeCS ID: 23607
Unique ID: D015224
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1989/01/01
Date of Entry: 1988/05/12
Revision Date: 1995/06/08
Dideoxynucleosides - Preferred
Concept UI M0023387
Scope note Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
Preferred term Dideoxynucleosides
Entry term(s) ddNus
2',3'-Dideoxynucleosides - Narrower
Concept UI M0023388
Preferred term 2',3'-Dideoxynucleosides
Entry term(s) 2',3' Dideoxynucleosides
Dideoxyribonucleosides - Narrower
Concept UI M0023389
Preferred term Dideoxyribonucleosides



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