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Descriptor English: Didanosine
Descriptor Spanish: Didanosina
Descriptor Portuguese: Didanosina
Descriptor French: Didéoxyinosine
Entry term(s): 2',3' Dideoxyinosine
2',3'-Dideoxyinosine
Dideoxyinosine
NSC 612049
NSC-612049
NSC612049
Videx
ddI (Antiviral)
Tree number(s): D03.633.100.759.590.616.130
D13.570.230.500.090
D13.570.583.616.130
D13.570.800.573.130
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016049
Scope note: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Registry Number: K3GDH6OH08
CAS Type 1 Name: Inosine, 2',3'-dideoxy-
Previous Indexing: Dideoxynucleosides (1989)
Inosine/analogs & derivatives (1987-1989)
Public MeSH Note: 92; was DIDEOXYINOSINE 1990-91
Online Note: use DIDANOSINE to search DIDEOXYINOSINE 1990-91
History Note: 92; was DIDEOXYINOSINE 1990-91
DeCS ID: 30328
Unique ID: D016049
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2017/05/24
Didanosine - Preferred
Concept UI M0024535
Scope note A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.
Preferred term Didanosine
Entry term(s) 2',3' Dideoxyinosine
2',3'-Dideoxyinosine
Dideoxyinosine
ddI (Antiviral)
Videx - Narrower
Concept UI M0024536
Preferred term Videx
NSC-612049 - Narrower
Concept UI M0328965
Preferred term NSC-612049
Entry term(s) NSC 612049
NSC612049



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