DeCS

Descriptor English:

Dideoxynucleosides

Descriptor Spanish:

Didesoxinucleósidos

Spanish from Spain

Descriptor	didesoxinucleósidos
Entry term(s)	2',3'-didesoxinucleósidos didesoxirribonucleósidos
Scope note:	Nucleósidos que no tienen dos grupos hidroxilos en la molécula de azúcar. La mayoría de estos compuestos tienen una actividad antirretrovírica de amplio espectro debido a su acción como antimetabolitos. Los nucleósidos se fosforilan intracelularmente a sus 5'-trifosfatos y actúan como inhibidores de la terminación de la cadena en la transcripción inversa vírica.

Descriptor Portuguese:

Didesoxinucleosídeos

Descriptor French:

Didéoxynucléosides

Tree number(s):

D13.570.230.500

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D015224

Scope note:

Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.

Annotation:

antivirals & antimetabolites

Allowable Qualifiers:

AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antimetabolites
Antiviral Agents
Reverse Transcriptase Inhibitors

DeCS ID:

23607

Unique ID:

D015224

Documents indexed in the Virtual Health Library (VHL):

Click here to access the VHL documents

Date Established:

1989/01/01

Date of Entry:

1988/05/12