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Descriptor English: Complement C1r
Descriptor Spanish: Complemento C1r
Descriptor complemento C1r
Scope note: Subcomponente del complemento C1, de 80 kDa, que existe como proenzima de la SERINA PROTEASA en el complejo del complemento C1 intacto. Cuando el COMPLEMENTO C1Q se une a anticuerpos, la estructura terciaria cambiada causa una activación autolítica del complemento C1r, que es dividido en dos cadenas -A (pesada) y B (ligera, la serina proteasa)- conectadas por enlaces disulfuro. La serina proteasa C1r activada, a su vez, activa a la proenzima del COMPLEMENTO C1S, mediante la división del enlace Arg426-Ile427. No se libera ningún fragmento en la escisión de C1r o C1s.
Descriptor Portuguese: Complemento C1r
Descriptor French: Complément C1r
Entry term(s): C1r Complement
C1r, Complement
Complement 1r
Complement Component 1r
Complement, C1r
Component 1r, Complement
Tree number(s): D08.811.277.300.280
D12.776.124.486.274.045.280
D12.776.124.486.274.050.280
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015923
Scope note: A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: EC 3.4.21.41
Previous Indexing: Complement 1 (1979-1989)
Complement Activating Enzymes (1979-1989)
Enzyme Precursors (1979-1982)
Public MeSH Note: 2006; see COMPLEMENT 1R 1990-2005
History Note: 2006 (1990)
DeCS ID: 24574
Unique ID: D015923
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2006/07/05
Complement C1r - Preferred
Concept UI M0024367
Scope note A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
Preferred term Complement C1r
Entry term(s) C1r Complement
C1r, Complement
Complement 1r
Complement Component 1r
Complement, C1r
Component 1r, Complement



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