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Descriptor English: Anaphylatoxins
Descriptor Spanish: Anafilatoxinas
Descriptor anafilatoxinas
Entry term(s) anafilatoxina
Scope note: Péptidos séricos derivados de ciertas PROTEÍNAS DEL COMPLEMENTO escindidas durante la ACTIVACIÓN DEL COMPLEMENTO. Inducen la CONTRACCIÓN MUSCULAR lisa, LIBERACIÓN DE HISTAMINA por las células cebadas, AGREGACIÓN PLAQUETARIA y actúan como mediadores en el proceso inflamatorio local. El orden de actividad anafilatoxínica de mayor a menor es C5a, C3a, C4a y C5a desarginina.
Descriptor Portuguese: Anafilatoxinas
Descriptor French: Anaphylatoxines
Entry term(s): Anaphylatoxin
Tree number(s): D12.776.124.486.274.024
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000706
Scope note: Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Previous Indexing: Complement (1968-1976)
Peptide Fragments (1974-1976)
Peptides (1966-1976)
specific complement (1975-1976)
Public MeSH Note: 90; was see under PEPTIDES 1977-89
History Note: 90(77); was see under PEPTIDES 1977-89
DeCS ID: 27941
Unique ID: D000706
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1976/05/19
Revision Date: 2018/07/02
Anaphylatoxins - Preferred
Concept UI M0001074
Scope note Serum peptides derived from certain cleaved COMPLEMENT PROTEINS during COMPLEMENT ACTIVATION. They induce smooth MUSCLE CONTRACTION; mast cell HISTAMINE RELEASE; PLATELET AGGREGATION; and act as mediators of the local inflammatory process. The order of anaphylatoxin activity from the strongest to the weakest is C5a, C3a, C4a, and C5a des-arginine.
Preferred term Anaphylatoxins
Entry term(s) Anaphylatoxin



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