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Descriptor English: Complement C5a
Descriptor Spanish: Complemento C5a
Descriptor complemento C5a
Scope note: El fragmento menor formado cuando la convertasa C5 desdobla C5 en C5a y COMPLEMENTO C5B. C5a es un glicopéptido de 74 aminoácidos con una ARGININA carboxi terminal que es crucial para su actividad espasmogénica. De todas las anafilatoxinas derivadas del complemento, C5a es la más potente en la mediación de la hipersensibilidad inmediata (HIPERSENSIBILIDAD INMEDIATA), CONTRACCIÓN DEL MÚSCULO liso, LIBERACIÓN DE HISTAMINA y migración de LEUCOCITOS al sitio de INFLAMACIÓN.
Descriptor Portuguese: Complemento C5a
Descriptor French: Complément C5a
Entry term(s): C5a Complement
C5a, Complement
Complement 5a
Complement Component 5a
Complement, C5a
Component 5a, Complement
Tree number(s): D12.776.124.486.274.024.270
D12.776.124.486.274.450.250
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D015936
Scope note: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Immunologic Factors
Registry Number: 80295-54-1
CAS Type 1 Name: Complement C5a
Previous Indexing: Anaphylatoxins (1977-1989)
Complement (1972-1975)
Complement 5 (1975-1989)
Public MeSH Note: 2006; see COMPLEMENT 5A 1990-2005
History Note: 2006 (1990)
DeCS ID: 24580
Unique ID: D015936
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2016/06/28
Complement C5a - Preferred
Concept UI M0024381
Scope note The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Preferred term Complement C5a
Entry term(s) C5a Complement
C5a, Complement
Complement 5a
Complement Component 5a
Complement, C5a
Component 5a, Complement



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