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Descriptor English:

Dideoxyadenosine

Descriptor Spanish:

Didesoxiadenosina

Spanish from Spain

Descriptor	didesoxiadenosina
Entry term(s)	2',3'-didesoxiadenosina ddA (antiviral)
Scope note:	Didesoxinucleosídico en el que el grupo 3'-hidroxi de la molécula de azúcar ha sido sustituido por un hidrógeno. Esta modificación impide la formación de los enlaces fosfodiéster que son necesarios para formar las cadenas de ácidos nucleicos. Este compuesto es un inhibidor de la replicación del VIH, que actúa como terminal de la cadena del ADN viral al unirse a la transcriptasa inversa. Su principal efecto secundario es la nefrotoxicidad. In vivo, la dideoxiadenosina se metaboliza rápidamente a DIDANOSINA (ddI) por la desaminación enzimática; ddI se convierte entonces en monofosfato de dideoxiinosina y, finalmente, en trifosfato de dideoxiadenosina, que es el metabolito putativo activo.

Descriptor Portuguese:

Didesoxiadenosina

Descriptor French:

Didéoxyadénosine

Tree number(s):

D03.633.100.759.590.138.325.105
D13.570.230.229.105
D13.570.230.500.105
D13.570.583.138.325.105

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016048

Scope note:

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.

Annotation:

an antiviral; inhibits HIV replication

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antimetabolites
Antiviral Agents

Registry Number:

4Q86AH641A

CAS Type 1 Name:

Adenosine, 2',3'-dideoxy-

DeCS ID:

24602

Unique ID:

D016048

Documents indexed in the Virtual Health Library (VHL):

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