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Descriptor English: Dideoxyadenosine
Descriptor Spanish: Didesoxiadenosina
Descriptor Portuguese: Didesoxiadenosina
Descriptor French: Didéoxyadénosine
Entry term(s): 2',3' Dideoxyadenosine
2',3'-Dideoxyadenosine
ddA (Antiviral)
Tree number(s): D03.633.100.759.590.138.325.105
D13.570.230.229.105
D13.570.230.500.105
D13.570.583.138.325.105
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016048
Scope note: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Annotation: an antiviral; inhibits HIV replication
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antimetabolites
Antiviral Agents
Registry Number: 4Q86AH641A
CAS Type 1 Name: Adenosine, 2',3'-dideoxy-
Previous Indexing: Deoxyadenosine/analogs & derivatives (1975-1989)
Dideoxynucleosides (1989)
Public MeSH Note: 90
History Note: 90
DeCS ID: 24602
Unique ID: D016048
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/07/14
Revision Date: 2016/05/31
Dideoxyadenosine - Preferred
Concept UI M0024534
Scope note A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is an inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal side effect is nephrotoxicity. In vivo, dideoxyadenosine is rapidly metabolized to DIDANOSINE (ddI) by enzymatic deamination; ddI is then converted to dideoxyinosine monophosphate and ultimately to dideoxyadenosine triphosphate, the putative active metabolite.
Preferred term Dideoxyadenosine
Entry term(s) 2',3' Dideoxyadenosine
2',3'-Dideoxyadenosine
ddA (Antiviral)



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