DeCS

Descriptor English:

1-Methyl-4-phenylpyridinium

Descriptor Spanish:

1-Metil-4-fenilpiridinio

Spanish from Spain

Descriptor	1-metil-4-fenilpiridinio
Entry term(s)	ciperquat
Scope note:	Metabolito neurotóxico activo de la 1-METIL-4-FENIL-1,2,3,6-TETRAHIDROPIRIDINA. Este compuesto reduce los niveles de dopamina, inhibe la biosíntesis de las catecolaminas, produce disminución cardíaca de norepinefrina e inactiva la tirosina hidroxilasa. Estos y otros efectos tóxicos provocan el cese de la fosforilacion oxidativa, depleción de ATP y muerte celular. Este compuesto, que está relacionado con el PARAQUAT, tambien se ha utilizado como herbicida.

Descriptor Portuguese:

1-Metil-4-fenilpiridínio

Descriptor French:

1-Méthyl-4-phényl-pyridinium

Entry term(s):

1-Méthyl-4-phénylpyridinium
Chlorure de 1-méthyl-4-phényl-pyridinium
Chlorure de 1-méthyl-4-phénylpyridinium

Tree number(s):

D03.383.725.762.550

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D015655

Scope note:

An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Herbicides

Registry Number:

R865A5OY8J

CAS Type 1 Name:

Pyridinium, 1-methyl-4-phenyl-

Intoxication au MPTP MeSH

DeCS ID:

24778

Unique ID:

D015655

Documents indexed in the Virtual Health Library (VHL):