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Descriptor English: Frameshift Mutation
Descriptor Spanish: Mutación del Sistema de Lectura
Descriptor mutación por desfase de lectura
Entry term(s) mutación del marco de lectura
mutación por cambio de marcos de lectura
Scope note: Tipo de mutación en la que algunos NUCLEÓTICOS eliminados de o insertados en una secuencia codificadora de proteínas no es divisible por tres, lo que causa una alteración en los MARCOS DE LECTURA de toda la secuencia de codificación a partir de la mutación. Estas mutaciones pueden ser inducidas por ciertos tipos de MUTÁGENOS o pueden surgir espontáneamente.
Descriptor Portuguese: Mutação da Fase de Leitura
Descriptor French: Mutation avec décalage du cadre de lecture
Entry term(s): Deletion, Out-of-Frame
Deletions, Out-of-Frame
Frame Shift Mutation
Frame Shift Mutations
Frameshift Mutations
Insertion, Out-of-Frame
Insertions, Out-of-Frame
Mutation, Frame Shift
Mutation, Frameshift
Mutation, Out-of-Frame
Mutations, Frame Shift
Mutations, Frameshift
Mutations, Out-of-Frame
Out of Frame Deletion
Out of Frame Insertion
Out of Frame Mutation
Out-of-Frame Deletion
Out-of-Frame Deletions
Out-of-Frame Insertion
Out-of-Frame Insertions
Out-of-Frame Mutation
Out-of-Frame Mutations
Tree number(s): G05.365.590.265
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016368
Scope note: A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
Annotation: do not confuse with FRAMESHIFTING, RIBOSOMAL, physiology process & form of genetic translation; do not confuse effects of drug & radiation on frameshift mutation with drug- & radiation-induced frameshift mutation
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Mutation (1968-1990)
Public MeSH Note: 91
History Note: 91
DeCS ID: 28941
Unique ID: D016368
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/05/25
Revision Date: 2008/07/08
Frameshift Mutation - Preferred
Concept UI M0025037
Scope note A type of mutation in which a number of NUCLEOTIDES deleted from or inserted into a protein coding sequence is not divisible by three, thereby causing an alteration in the READING FRAMES of the entire coding sequence downstream of the mutation. These mutations may be induced by certain types of MUTAGENS or may occur spontaneously.
Preferred term Frameshift Mutation
Entry term(s) Frame Shift Mutation
Frame Shift Mutations
Frameshift Mutations
Mutation, Frame Shift
Mutation, Frameshift
Mutation, Out-of-Frame
Mutations, Frame Shift
Mutations, Frameshift
Mutations, Out-of-Frame
Out of Frame Mutation
Out-of-Frame Mutation
Out-of-Frame Mutations
Out-of-Frame Insertion - Narrower
Concept UI M0506653
Preferred term Out-of-Frame Insertion
Entry term(s) Insertion, Out-of-Frame
Insertions, Out-of-Frame
Out of Frame Insertion
Out-of-Frame Insertions
Out-of-Frame Deletion - Narrower
Concept UI M0471538
Preferred term Out-of-Frame Deletion
Entry term(s) Deletion, Out-of-Frame
Deletions, Out-of-Frame
Out of Frame Deletion
Out-of-Frame Deletions



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