DeCS

Descriptor English:

Mutagenesis, Insertional

Descriptor Spanish:

Mutagénesis Insercional

Spanish from Spain

Descriptor	mutagénesis por inserción
Entry term(s)	activación por inserción inserción de secuencias inserción génica mutación por inserción mutagénesis por inserción de casete mutagénesis por inserción viral
Scope note:	Mutagénesis en la que la mutación es provocada por la introducción de secuencias extrañas de ADN en una secuencia génica o extragénica. Esto puede ocurrir espontáneamente in vivo o inducirse experimentalmente in vivo o in vitro. Las inserciones de ADN provírico en un protooncogén celular o adyacente al mismo pueden interrumpir la TRADUCCIÓN GENÉTICA de las secuencias codificadoras o interferir con el reconocimiento de elementos reguladores y dar lugar a una expresión no regulada del protooncogén, con la consiguiente formación de tumores.

Descriptor Portuguese:

Mutagênese Insercional

Descriptor French:

Mutagenèse par insertion

Entry term(s):

Activation, Insertional
Activations, Insertional
Cassette Mutagenesis
Gene Insertion
Gene Insertions
Insertion Mutation
Insertion Mutations
Insertion, Gene
Insertion, Sequence
Insertional Activation
Insertional Activations
Insertional Mutagenesis
Insertional Mutagenesis, Viral
Insertions, Gene
Insertions, Sequence
Linker Insertion Mutagenesis
Linker-Insertion Mutagenesis
Mutagenesis, Cassette
Mutagenesis, Linker-Insertion
Mutagenesis, Viral Insertional
Mutation, Insertion
Mutations, Insertion
Sequence Insertion
Sequence Insertions
Viral Insertional Mutagenesis

Tree number(s):

E05.393.420.601.550
G05.365.590.575
G05.558.550

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D016254

Scope note:

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

Allowable Qualifiers:

DE drug effects
EC economics
GE genetics
HI history
IM immunology
IS instrumentation
MT methods
PH physiology
RE radiation effects
SN statistics & numerical data
ST standards

Concept UI	M0024827
Scope note	Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Preferred term	Mutagenesis, Insertional
Entry term(s)	Insertional Mutagenesis

Concept UI	M0506944
Preferred term	Sequence Insertion
Entry term(s)	Insertion, Sequence Insertions, Sequence Sequence Insertions

Concept UI	M0024828
Preferred term	Viral Insertional Mutagenesis
Entry term(s)	Insertional Mutagenesis, Viral Mutagenesis, Viral Insertional

Concept UI	M0024825
Preferred term	Linker-Insertion Mutagenesis
Entry term(s)	Linker Insertion Mutagenesis Mutagenesis, Linker-Insertion

Concept UI	M0506942
Preferred term	Gene Insertion
Entry term(s)	Gene Insertions Insertion, Gene Insertions, Gene

Concept UI	M0506943
Preferred term	Insertion Mutation
Entry term(s)	Insertion Mutations Mutation, Insertion Mutations, Insertion

Concept UI	M0024824
Preferred term	Insertional Activation
Entry term(s)	Activation, Insertional Activations, Insertional Insertional Activations

Concept UI	M0024826
Preferred term	Mutagenesis, Cassette
Entry term(s)	Cassette Mutagenesis

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